دورية أكاديمية

Cisplatin-activated and hemoglobin-mediated injectable hydrogel system for antitumor chemodynamic and chemotherapy

التفاصيل البيبلوغرافية
العنوان: Cisplatin-activated and hemoglobin-mediated injectable hydrogel system for antitumor chemodynamic and chemotherapy
المؤلفون: Hsun-Tzu Tsen, Tzu-Chieh Sun, To-Kai Lai, Wei-Yuan Huang, Huan-Chih Wang, Tsai-Te Lu, Tzu-Wei Wang
المصدر: Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116713- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: Injectable hydrogel, Reactive oxygen species, Hemoglobin, Chemotherapy, Chemodynamic therapy, Glioblastoma, Therapeutics. Pharmacology, RM1-950
الوصف: Low specificity and hypoxia-induced drug resistance are significant challenges in traditional cancer treatment. To enhance the anticancer efficacy, an injectable hydrogel system is developed through the formation of dynamic covalent bonds in hyaluronic acid, allowing for localized controlled release of drugs. This system also utilizes double-stranded DNA sequences for the intercalation delivery of the chemotherapeutic drug, enabling a multifaceted approach to therapy. Cisplatin not only serves as a chemotherapy drug but also acts as a catalyst for chemodynamic therapy (CDT) to initiate CDT cascades by creating hydrogen peroxide for the Fenton reaction. Hemoglobin, enclosed in PLGA nanoparticles, provides ferrous ions that react with hydrogen peroxide in an acidic environment, yielding hydroxyl radicals that induce cancer cell death. Additionally, oxygen released from hemoglobin mitigates hypoxia-induced chemoresistance, bolstering overall anticancer efficacy. Results demonstrate the shear-thinning properties and injectability of the hydrogel. Cisplatin elevates intracellular hydrogen peroxide levels in tumor cells, while hemoglobin efficiently releases ferrous ions and generates reactive oxygen species (ROS) in the presence of hydrogen peroxide. In in vitro and in vivo study, the combinational use of chemo- and chemodynamic therapies achieves a synergistic anticancer effect on combating glioblastoma. In summary, our CDT-based hydrogel, activated by endogenous cues and mediated by chemo drugs, spontaneously produces ROS and ameliorates the adverse tumor microenvironment with rational and selective antitumor strategies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0753-3322
33947279
Relation: http://www.sciencedirect.com/science/article/pii/S0753332224005973; https://doaj.org/toc/0753-3322
DOI: 10.1016/j.biopha.2024.116713
URL الوصول: https://doaj.org/article/8d50c713c339472796a827453cf673e9
رقم الأكسشن: edsdoj.8d50c713c339472796a827453cf673e9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:07533322
33947279
DOI:10.1016/j.biopha.2024.116713