دورية أكاديمية
Cisplatin-activated and hemoglobin-mediated injectable hydrogel system for antitumor chemodynamic and chemotherapy
العنوان: | Cisplatin-activated and hemoglobin-mediated injectable hydrogel system for antitumor chemodynamic and chemotherapy |
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المؤلفون: | Hsun-Tzu Tsen, Tzu-Chieh Sun, To-Kai Lai, Wei-Yuan Huang, Huan-Chih Wang, Tsai-Te Lu, Tzu-Wei Wang |
المصدر: | Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116713- (2024) |
بيانات النشر: | Elsevier, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Therapeutics. Pharmacology |
مصطلحات موضوعية: | Injectable hydrogel, Reactive oxygen species, Hemoglobin, Chemotherapy, Chemodynamic therapy, Glioblastoma, Therapeutics. Pharmacology, RM1-950 |
الوصف: | Low specificity and hypoxia-induced drug resistance are significant challenges in traditional cancer treatment. To enhance the anticancer efficacy, an injectable hydrogel system is developed through the formation of dynamic covalent bonds in hyaluronic acid, allowing for localized controlled release of drugs. This system also utilizes double-stranded DNA sequences for the intercalation delivery of the chemotherapeutic drug, enabling a multifaceted approach to therapy. Cisplatin not only serves as a chemotherapy drug but also acts as a catalyst for chemodynamic therapy (CDT) to initiate CDT cascades by creating hydrogen peroxide for the Fenton reaction. Hemoglobin, enclosed in PLGA nanoparticles, provides ferrous ions that react with hydrogen peroxide in an acidic environment, yielding hydroxyl radicals that induce cancer cell death. Additionally, oxygen released from hemoglobin mitigates hypoxia-induced chemoresistance, bolstering overall anticancer efficacy. Results demonstrate the shear-thinning properties and injectability of the hydrogel. Cisplatin elevates intracellular hydrogen peroxide levels in tumor cells, while hemoglobin efficiently releases ferrous ions and generates reactive oxygen species (ROS) in the presence of hydrogen peroxide. In in vitro and in vivo study, the combinational use of chemo- and chemodynamic therapies achieves a synergistic anticancer effect on combating glioblastoma. In summary, our CDT-based hydrogel, activated by endogenous cues and mediated by chemo drugs, spontaneously produces ROS and ameliorates the adverse tumor microenvironment with rational and selective antitumor strategies. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 0753-3322 33947279 |
Relation: | http://www.sciencedirect.com/science/article/pii/S0753332224005973; https://doaj.org/toc/0753-3322 |
DOI: | 10.1016/j.biopha.2024.116713 |
URL الوصول: | https://doaj.org/article/8d50c713c339472796a827453cf673e9 |
رقم الأكسشن: | edsdoj.8d50c713c339472796a827453cf673e9 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 07533322 33947279 |
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DOI: | 10.1016/j.biopha.2024.116713 |