دورية أكاديمية
Unraveling the structure, chemical composition, and conserved signaling in leech teeth
| العنوان: | Unraveling the structure, chemical composition, and conserved signaling in leech teeth |
|---|---|
| المؤلفون: | Yam Prasad Aryal, Sanjiv Neupane, Hee-Jin Kwak, Chang-Hyeon An, Wern-Joo Sohn, Hitoshi Yamamoto, Tae-Yub Kwon, Bong-Ki Min, Jae-Young Kim, Sung-Jin Cho |
| المصدر: | Animal Cells and Systems, Vol 28, Iss 1, Pp 272-282 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Leech, teeth, transcriptome analysis, conserved signaling, chemical nature, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | ABSTRACTUnlike vertebrates, the number of toothed taxa in invertebrates is very few, with leeches being the only tooth-bearing organisms in the phylum Annelida. Copious studies have been conducted regarding vertebrate teeth; however, studies regarding the structure and function of invertebrate teeth are limited. In this study, the tooth structure of leeches, specifically Hirudo nipponia and Haemadipsa rjukjuana, was revealed, which showed sharp and pointed teeth along the apex of three jaws. Understanding conserved signaling regulations among analogous organs is crucial for uncovering the underlying mechanisms during organogenesis. Therefore, to shed light on the evolutionary perspective of odontogenesis to some extent, we conducted de novo transcriptome analyses using embryonic mouse tooth germs, Hirudo teeth, and Helobdella proboscises to identify conserved signaling molecules involved in tooth development. The selection criteria were particularly based on the presence of tooth-related genes in mice, Hirudo teeth, and Helobdella proboscis, wherein 4113 genes were commonly expressed in all three specimens. Furthermore, the chemical nature of leech teeth was also examined via TEM-EDS to compare the chemical composition with vertebrate teeth. The examination of tissue-specific genetic information and chemical nature between leeches and mice revealed chemical similarities between leech and mice teeth, as well as conserved signaling molecules involved in tooth formation, including Ptpro, Prickle2, and Wnt16. Based on our findings, we propose that leech teeth express signaling molecules conserved in mice and these conserved tooth-specific signaling for dental hard tissue formation in mice would corresponds to the structural formation of the toothed jaw in leeches. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19768354 2151-2485 1976-8354 |
| Relation: | https://doaj.org/toc/1976-8354; https://doaj.org/toc/2151-2485 |
| DOI: | 10.1080/19768354.2024.2350736 |
| URL الوصول: | https://doaj.org/article/ee8da47b124b455d915ec16623a5a1df |
| رقم الأكسشن: | edsdoj.8da47b124b455d915ec16623a5a1df |
| قاعدة البيانات: | Directory of Open Access Journals |
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