دورية أكاديمية
Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review
| العنوان: | Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review |
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| المؤلفون: | Carolina Rios-Usuga, Marlen Martinez-Gutierrez, Julian Ruiz-Saenz |
| المصدر: | Pharmaceuticals, Vol 17, Iss 2, p 174 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | azathioprine, antimetabolite, autoimmune, hepatotoxicity, antiviral, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | The use of azathioprine (AZA) in human medicine dates back to research conducted in 1975 that led to the development of several drugs, including 6-mercaptopurine. In 1958, it was shown that 6-mercaptopurine decreased the production of antibodies against earlier administered antigens, raising the hypothesis of an immunomodulatory effect. AZA is a prodrug that belongs to the thiopurine group of drugs that behave as purine analogs. After absorption, it is converted into 6-mercaptopurine. Subsequently, it can be degraded through various enzymatic pathways into inactive compounds and biologically active compounds related to the mechanism of action, which has been the subject of study to evaluate a possible antiviral effect. This study aims to examine the metabolism, mechanism of action, and antiviral potential of AZA and its derivatives, exploring AZA impact on antiviral targets and adverse effects through a narrative literature review. Ultimately, the review will provide insights into the antiviral mechanism, present evidence of its in vitro effectiveness against various DNA and RNA viruses, and suggest in vivo studies to further demonstrate its antiviral effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 17020174 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/17/2/174; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph17020174 |
| URL الوصول: | https://doaj.org/article/e8edb4bada29451f97ba58ffe304a990 |
| رقم الأكسشن: | edsdoj.8edb4bada29451f97ba58ffe304a990 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17020174 14248247 |
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| DOI: | 10.3390/ph17020174 |