دورية أكاديمية
Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice
| العنوان: | Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice |
|---|---|
| المؤلفون: | Woohyun Kim, Jae Jin Shin, Yu Jin Jeong, Kyungdeok Kim, Jung Won Bae, Young Woo Noh, Seungjoon Lee, Woochul Choi, Se-Bum Paik, Min Whan Jung, Eunee Lee, Eunjoon Kim |
| المصدر: | eLife, Vol 11 (2022) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | firing variability, IRSp53, medial prefrontal cortex, social behavior, BAIAP2, social deficit, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) of IRSp53/Baiap2-mutant mice, which show social deficits, during social approach. We found a decrease in the proportion of IRSp53-mutant excitatory mPFC neurons encoding social information, but not that encoding non-social information. In addition, the firing activity of IRSp53-mutant neurons was less differential between social and non-social targets. IRSp53-mutant excitatory mPFC neurons displayed an increase in baseline neuronal firing, but decreases in the variability and dynamic range of firing as well as burst firing during social and non-social target approaches compared to wild-type controls. Treatment of memantine, an NMDA receptor antagonist that rescues social deficit in IRSp53-mutant mice, alleviates the reduced burst firing of IRSp53-mutant pyramidal mPFC neurons. These results suggest that suppressed neuronal activity dynamics and burst firing may underlie impaired cortical encoding of social information and social behaviors in IRSp53-mutant mice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/74998; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.74998 |
| URL الوصول: | https://doaj.org/article/d8f5356a8bfc458cb2ef94ae9e3b671f |
| رقم الأكسشن: | edsdoj.8f5356a8bfc458cb2ef94ae9e3b671f |
| قاعدة البيانات: | Directory of Open Access Journals |
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