دورية أكاديمية
Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products
| العنوان: | Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products |
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| المؤلفون: | Thomas A. Mackenzie, José R. Tormo, Bastien Cautain, Germán Martínez, Isabel Sánchez, Olga Genilloud, Francisca Vicente, Maria C. Ramos |
| المصدر: | SLAS Technology, Vol 29, Iss 3, Pp 100111- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Acoustic droplet ejection (ADE), Natural products (NP), High throughput screening (HTS), Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Natural Products (NPs) are one of the main sources for drug discovery. Many clinical drugs are NPs or NP-inspired compounds, and recently discovered New Chemical Entities (NCEs) of NPs are emerging as promising new drugs. High-Throughput Screening (HTS) of large sample sets or libraries has grown to be vital for the drug discovery field. Industrial-scale HTS of NP libraries can be limited due to the difficulties entailed in working with tiny extract volumes and the variability in viscosity of NP extracts. For these reasons, the implementation of new technologies to miniaturize different reagent volumes grows to be fundamental. Since Acoustic Droplet Ejection (ADE) emerged as a helpful tool in HTS campaigns for the transference of compound libraries. The aim of this work was to test the effectiveness of ADE for the dispensation of NP extract libraries in cell-based HTS assays. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2472-6303 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2472630323000626; https://doaj.org/toc/2472-6303 |
| DOI: | 10.1016/j.slast.2023.10.003 |
| URL الوصول: | https://doaj.org/article/8fd4b72cc19c459ea5afb4fb95a2858d |
| رقم الأكسشن: | edsdoj.8fd4b72cc19c459ea5afb4fb95a2858d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24726303 |
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| DOI: | 10.1016/j.slast.2023.10.003 |