دورية أكاديمية
أعرض في EDS

Diffusion kurtosis and quantitative susceptibility mapping MRI are sensitive to structural abnormalities in amyotrophic lateral sclerosis

التفاصيل البيبلوغرافية
العنوان: Diffusion kurtosis and quantitative susceptibility mapping MRI are sensitive to structural abnormalities in amyotrophic lateral sclerosis
المؤلفون: Thomas Welton, Jerome J. Maller, R. Marc Lebel, Ek T. Tan, Dominic B. Rowe, Stuart M. Grieve
المصدر: NeuroImage: Clinical, Vol 24, Iss , Pp - (2019)
بيانات النشر: Elsevier, 2019.
سنة النشر: 2019
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
الوصف: Objective: To construct a clinical diagnostic biomarker using state-of-the-art microstructural MRI in the motor cortex of people with amyotrophic lateral sclerosis (ALS). Methods: Clinical and MRI data were obtained from 21 ALS patients (aged 54 ± 14 years, 33% female) and 63 age- and gender-matched controls (aged 48 ± 18 years, 43% female). MRI was acquired at 3T and included T1-weighted scan (for volumetrics), arterial spin labelling (for cerebral blood flow), susceptibility-weighted angiography (for iron deposition) and multiband diffusion kurtosis imaging (for tissue microstructure). Group differences in imaging measures in the motor cortex were tested by general linear model and relationships to clinical variables by linear regression. Results: The ALS group had mild-to-moderate impairment (disease duration: 1.8 ± 0.8 years; ALS functional rating scale 40.2 ± 6.0; forced vital capacity 83% ± 22%). No age or gender differences were present between groups. We found significant group differences in diffusion kurtosis metrics (apparent, mean, radial and axial kurtosis: p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-1582
Relation: http://www.sciencedirect.com/science/article/pii/S2213158219303031; https://doaj.org/toc/2213-1582
DOI: 10.1016/j.nicl.2019.101953
URL الوصول: https://doaj.org/article/90bcab37d5cc45a888f6997b29127c51
رقم الأكسشن: edsdoj.90bcab37d5cc45a888f6997b29127c51
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22131582
DOI:10.1016/j.nicl.2019.101953