دورية أكاديمية
The effects of 4-Phenylbutyric acid on ER stress during mouse tooth development
| العنوان: | The effects of 4-Phenylbutyric acid on ER stress during mouse tooth development |
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| المؤلفون: | Eui-Seon Lee, Yam Prasad Aryal, Tae-Young Kim, Elina Pokharel, Ji-Youn Kim, Hitoshi Yamamoto, Chang-Hyeon An, Seo-Young An, Jae-Kwang Jung, Youngkyun Lee, Jung-Hong Ha, Wern-Joo Sohn, Jae-Young Kim |
| المصدر: | Frontiers in Physiology, Vol 13 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Physiology |
| مصطلحات موضوعية: | chemical chaperones, dentinogenesis, morphogenesis, secretion, signaling, Physiology, QP1-981 |
| الوصف: | Introduction: During tooth development, proper protein folding and trafficking are significant processes as newly synthesized proteins proceed to form designated tissues. Endoplasmic reticulum (ER) stress occurs inevitably in tooth development as unfolded and misfolded proteins accumulate in ER. 4-Phenylbutyric acid (4PBA) is a FDA approved drug and known as a chemical chaperone which alleviates the ER stress. Recently, several studies showed that 4PBA performs therapeutic effects in some genetic diseases due to misfolding of proteins, metabolic related-diseases and apoptosis due to ER stress. However, the roles of 4PBA during odontogenesis are not elucidated. This study revealed the effects of 4PBA during molar development in mice.Methods: We employed in vitro organ cultivation and renal transplantation methods which would mimic the permanent tooth development in an infant period of human. The in vitro cultivated tooth germs and renal calcified teeth were examined by histology and immunohistochemical analysis.Results and Discussion: Our results revealed that treatment of 4PBA altered expression patterns of enamel knot related signaling molecules, and consequently affected cellular secretion and patterned formation of dental hard tissues including dentin and enamel during tooth morphogenesis. The alteration of ER stress by 4PBA treatment during organogenesis would suggest that proper ER stress is important for pattern formation during tooth development and morphogenesis, and 4PBA as a chemical chaperone would be one of the candidate molecules for dental and hard tissue regeneration. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-042X 33214840 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1079355/full; https://doaj.org/toc/1664-042X |
| DOI: | 10.3389/fphys.2022.1079355 |
| URL الوصول: | https://doaj.org/article/90d332148403423d98025c02f7e075ae |
| رقم الأكسشن: | edsdoj.90d332148403423d98025c02f7e075ae |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1664042X 33214840 |
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| DOI: | 10.3389/fphys.2022.1079355 |