دورية أكاديمية
A meta-analysis of VDR polymorphisms and postmenopausal osteoporosis
العنوان: | A meta-analysis of VDR polymorphisms and postmenopausal osteoporosis |
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المؤلفون: | Lijuan Fu, Jinhuan Ma, Sumei Yan, Qijun Si |
المصدر: | Endocrine Connections, Vol 9, Iss 9, Pp 882-889 (2020) |
بيانات النشر: | Bioscientifica, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
مصطلحات موضوعية: | postmenopausal osteoporosis (pmop), vitamin d receptor (vdr), gene polymorphisms, meta-analysis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
الوصف: | Background: Whether polymorphisms in VDR gene affect the risk of postmenopausal osteoporosis or not remain unclear. Thus, the authors performed a meta-analysis to more robustly assess associations between polymorphisms in VDR gene and the risk of postmenopausal osteoporosis by integrating the results of previous literature. Methods: Medline, Embase, Wanfang, VIP and CNKI were searched comprehensively for eligible literature, and 67 genetic association studies were fin ally selected to be included in this meta-analysis. Results: We found that ApaI rs7975232 (dominant comparison: OR = 0.77, P = 0.007; allele comparison: OR = 0.81, P = 0.04), BsmI rs1544410 (dominant comparison: OR = 0.69, P = 0.002; allele comparison: OR = 0.78, P = 0.008) and TaqI rs731236 (recessive comparison: OR = 1.32 , P = 0.01) polymorphisms were significantly associated with the risk of postmenopausal osteoporosis in Caucasians, whereas FokI rs10735810 polymorphism was significantly associated with the risk of postm enopausal osteoporosis in Asians (dominant comparison: OR = 0.61, P = 0.0001; recessive comparison: OR = 2.02, P = 0.001; allele comparison: OR = 0.68, P = 0.002). Conclusions: This meta-analysis shows that ApaI rs7975232, BsmI rs1544410 a nd TaqI rs731236 polymorphisms may affect the risk of postmenopausal ost eoporosis in Caucasians, while BsmI rs1544410 polymorphism may affect the ris k of postmenopausal osteoporosis in Asians. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2049-3614 |
Relation: | https://ec.bioscientifica.com/view/journals/ec/9/9/EC-20-0296.xml; https://doaj.org/toc/2049-3614 |
DOI: | 10.1530/EC-20-0296 |
URL الوصول: | https://doaj.org/article/a910ad3d8a364cafa1d6870265072d5c |
رقم الأكسشن: | edsdoj.910ad3d8a364cafa1d6870265072d5c |
قاعدة البيانات: | Directory of Open Access Journals |
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