دورية أكاديمية
Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter
| العنوان: | Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter |
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| المؤلفون: | Veenu Tripathi, Ying E. Zhang |
| المصدر: | Molecular & Cellular Oncology, Vol 4, Iss 1 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | alternative splicing, emt, metastasis, pcbp1, smad3, tgf-β, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2372-3556 23723556 |
| Relation: | https://doaj.org/toc/2372-3556 |
| DOI: | 10.1080/23723556.2016.1265699 |
| URL الوصول: | https://doaj.org/article/c917c82d5eaf43ed8762c4bfd3e2cea5 |
| رقم الأكسشن: | edsdoj.917c82d5eaf43ed8762c4bfd3e2cea5 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 23723556 |
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| DOI: | 10.1080/23723556.2016.1265699 |