دورية أكاديمية
LiveBoost: A GB-based prediction system for liver fibrosis in chronic hepatitis B patients in China - A multi-center retrospective study
| العنوان: | LiveBoost: A GB-based prediction system for liver fibrosis in chronic hepatitis B patients in China - A multi-center retrospective study |
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| المؤلفون: | Guoxiang Xie, Huanming Xiao, Quan Liu, Tianlu Chen, Fengyan Chen, Kejun Zhou, Xiaoning Wang, Ping Liu, Zhifeng Jia, Lei Chen, Xin Deng, Fankun Meng, Zhenhua Zhang, Xiaoling Chi, Wei Jia |
| المصدر: | Heliyon, Vol 10, Iss 2, Pp e24161- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Hepatic fibrosis, FIB-4, APRI, Chronic hepatitis B, LiveBoost, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Background: The aim of this study was to evaluate the accuracy of LiveBoost™, a gradient boosting (GB)-based prediction system based on standard biochemical values (AST, ALT, platelet count) and age, in Chinese patients with chronic hepatitis B (CHB) and compare its performance with FIB-4 (fibrosis-4 score) and APRI (the aspartate transaminase to platelet ratio index). Methods: This retrospective trial enrolled 454 participants, including 279 CHB patients who underwent liver biopsy and 175 normal controls from 3 centers in China. All participants underwent laboratory blood testing. LiveBoost was constructed using GB and FIB-4 and APRI were calculated from laboratory data. Results: LiveBoost outperformed APRI and FIB-4 in predicting hepatic fibrosis and cirrhosis. The GB model had an AUROC of 0.977 for CHB diagnosis, 0.804 for early and advanced fibrosis, and 0.836 for non-cirrhosis and cirrhosis, compared to AUROC of 0.554, 0.673 and 0.720 for FIB-4, AUROC of 0.977, 0.652 and 0.654 for APRI. Conclusions: LiveBoost is a more reliable and cost-effective method than APRI and FIB-4 for assessing liver fibrosis in Chinese patients with CHB. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024001920; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e24161 |
| URL الوصول: | https://doaj.org/article/921dcc8f764f4d2697328d8a68589015 |
| رقم الأكسشن: | edsdoj.921dcc8f764f4d2697328d8a68589015 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e24161 |