دورية أكاديمية
أعرض في EDS

Sofosbuvir‐based therapies in genotype 2 hepatitis C virus cirrhosis: A real‐life experience with focus on ribavirin dose

التفاصيل البيبلوغرافية
العنوان: Sofosbuvir‐based therapies in genotype 2 hepatitis C virus cirrhosis: A real‐life experience with focus on ribavirin dose
المؤلفون: Carlo Smirne, Antonio D'Avolio, Mattia Bellan, Alessandro Gualerzi, Maria G. Crobu, Mario Pirisi
المصدر: Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
بيانات النشر: Wiley, 2021.
سنة النشر: 2021
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: anemia, cirrhosis, hepatitis C, ribavirin, sofosbuvir, Therapeutics. Pharmacology, RM1-950
الوصف: Abstract This study aimed to investigate the efficacy and safety of sofosbuvir‐based therapies for the treatment of cirrhosis from hepatitis C virus (HCV) genotype 2 infection. Data of all consecutive HCV genotype 2 cirrhotic patients who started sofosbuvir‐based treatments between January 2015 and March 2017 in eight Italian tertiary hospitals were collected retrospectively. Overall, 273 patients (Child A: 94.5%) were enrolled. In the 194 subjects treated with sofosbuvir/ribavirin, median initial ribavirin dosage was 13.9 mg/kg/day, and therapy duration was 16 weeks. Sustained virological response (SVR) rates were 93.8% in intention‐to‐treat (ITT) and 95.3% in per‐protocol (PP) analyses for the 129 treatment‐naïve patients, and 96.9% (ITT) and 98.4% (PP) for the 65 treatment‐experienced subjects. Adverse events were reported in 142 patients (73.2%), but only 1.5% discontinued treatment. Eighty‐eight subjects with treatment‐induced anemia (mild: 34.5%, moderate: 7.7%, severe: 3.1%) had to reduce ribavirin dosage, but SVR rates were comparable to the weight‐based dose group, both in ITT (95.4% and 94.3%) and PP (97.7% and 95.2%) analyses, respectively. Moreover, ITT and PP SVR rates were similar between shorter (
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2052-1707
Relation: https://doaj.org/toc/2052-1707
DOI: 10.1002/prp2.811
URL الوصول: https://doaj.org/article/ae924c3d0bb347cfa1acf4676a017a46
رقم الأكسشن: edsdoj.924c3d0bb347cfa1acf4676a017a46
قاعدة البيانات: Directory of Open Access Journals
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا