دورية أكاديمية

Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity

التفاصيل البيبلوغرافية
العنوان: Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity
المؤلفون: Hong-Yi Zhao, Shu-Di Zhang, Kai Zhang, Xi Wang, Qing-Yan Zhao, Shu-Juan Zhang, Zi-Xuan Dai, Yong-Sheng Qian, You-Jing Zhang, Hao-Tian Wei, Yan-Hong Tang, Cong-Xin Huang
المصدر: Chinese Medical Journal, Vol 130, Iss 2, Pp 171-178 (2017)
بيانات النشر: Wolters Kluwer, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
مصطلحات موضوعية: Atrial Fibrillation, Autonomic Nerve, Cholinergic Anti-inflammatory Pathway, Inflammatory Cytokines, Shensong Yangxin, Medicine
الوصف: Background: Shensong Yangxin (SSYX), a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation (AF) is unknown. In this study, we tested the hypothesis that the effect of SSYX on the progression of paroxysmal AF is correlated with the regulation of autonomic nerve activity. Methods: Eighteen mongrel dogs were randomly divided into control group (n = 6), pacing group (n = 6), and pacing + SSYX group (n = 6). The control group was implanted with pacemakers without pacing; the pacing group was implanted with pacemakers with long-term intermittent atrial pacing; the pacing + SSYX group underwent long-term intermittent atrial pacing and SSYX oral administration. Results: Compared to the pacing group, the parameters of heart rate variability were lower after 8 weeks in the pacing + SSYX group (low-frequency [LF] component: 20.85 ± 3.14 vs. 15.3 ± 1.89 ms 2 , P = 0.004; LF component/high-frequency component: 1.34 ± 0.33 vs. 0.77 ± 0.15, P < 0.001). The atrial effective refractory period (AERP) was shorter and the dispersion of the AERP was higher after 8 weeks in the pacing group, while the changes were suppressed by SSYX intake. The dogs in the pacing group had more episodes and longer durations of AF than that in the pacing + SSYX group. SSYX markedly inhibited the increase in sympathetic nerves and upregulation of tumor necrosis factor-alpha and interleukin-6 expression in the pacing + SSYX group. Furthermore, SSYX suppressed the decrease of acetylcholine and α7 nicotinic acetylcholine receptor protein induced by long-term intermittent atrial pacing. Conclusions: SSYX substantially prevents atrial electrical remodeling and the progression of AF. These effects of SSYX may have association with regulating the imbalance of autonomic nerve activity and the cholinergic anti-inflammatory pathway.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0366-6999
Relation: http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=2;spage=171;epage=178;aulast=Zhao; https://doaj.org/toc/0366-6999
DOI: 10.4103/0366-6999.197997
URL الوصول: https://doaj.org/article/ad9294dcde2f4ab2a5dee716bf437905
رقم الأكسشن: edsdoj.9294dcde2f4ab2a5dee716bf437905
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:03666999
DOI:10.4103/0366-6999.197997