A case of Bowen's disease of toe is reported. A 39-year-old woman presented with red asymptomatic lesion on the medial side of the left big toe for over a month. Topical treatment with glucocorticoid was not effective. A similar rash appeared on the same area 5 to 6 years ago, and was surgically removed. Clinical examination revealed a demarcated red plaque 1.5 cm×1.5 cm in diameter, with dark red crust in the center, on her big left toe. The histopathological examination of the skin lesion showed heteroplasia of the squamous epithelium in the epidermis. The diagnosis was Bowen's disease. Following removal of lesion with electrocauterization, 5-aminolevulinic acid photodynamic (ALA-PDT) was given 4 times. The lesion completely subsided with no recurrence during 1-year telephone follow-up.
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