دورية أكاديمية
MyD88 Signaling Accompanied by Microbiota Changes Supports Urinary Bladder Carcinogenesis
| العنوان: | MyD88 Signaling Accompanied by Microbiota Changes Supports Urinary Bladder Carcinogenesis |
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| المؤلفون: | Dora Knezović, Blanka Milić Roje, Katarina Vilović, Lucija Franković, Jelena Korac-Prlic, Janoš Terzić |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 13, p 7176 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | urinary bladder neoplasms, myeloid differentiation factor 88, Toll-like receptor 4, microbiota, Faecalibaculum, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Urinary bladder cancer (BC) inflicts a significant impairment of life quality and poses a high mortality risk. Schistosoma haematobium infection can cause BC, and the urinary microbiota of BC patients differs from healthy controls. Importantly, intravesical instillation of the bacterium Bacillus Calmette-Guerin stands as the foremost therapy for non-muscle invasive BC. Hence, studying the receptors and signaling molecules orchestrating bacterial recognition and the cellular response in the context of BC is of paramount importance. Thus, we challenged Toll-like receptor 4 (Tlr4) and myeloid differentiation factor 88 (Myd88) knock-out (KO) mice with N-butyl-N-(4-hydroxylbutyl)-nitrosamine (BBN), a well-known urinary bladder carcinogen. Gut microbiota, gene expression, and urinary bladder pathology were followed. Acute exposure to BBN did not reveal a difference in bladder pathology despite differences in the animal’s ability to recognize and react to bacteria. However, chronic treatment resulted in reduced cancer invasiveness among Myd88KO mice while the absence of functional Tlr4 did not influence BC development or progression. These differences correlate with a heightened abundance of the Faecalibaculum genus and the lowest microbial diversity observed among Myd88KO mice. The presented data underscore the important role of microbiota composition and MyD88-mediated signaling during bladder carcinogenesis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/13/7176; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25137176 |
| URL الوصول: | https://doaj.org/article/94a6b4f7e4e54d8cb6a0277d572b1f65 |
| رقم الأكسشن: | edsdoj.94a6b4f7e4e54d8cb6a0277d572b1f65 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25137176 |