دورية أكاديمية
New Treatment Addressing the Pathogenesis of Psoriasis
| العنوان: | New Treatment Addressing the Pathogenesis of Psoriasis |
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| المؤلفون: | Michio Tokuyama, Tomotaka Mabuchi |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 20, p 7488 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | psoriasis, new treatment, pathogenesis, dendritic cells, Janus kinase inhibitor, sphingosine 1-phosphate receptor 1, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Psoriasis is an immune cell-mediated inflammatory skin disease. The interleukin (IL)23/IL17 axis plays an important role in the development of psoriasis. The effectiveness of biologic treatments such as tumor necrosis factor (TNF)α inhibitors (infliximab, adalimumab, certolizumab pegol), IL23 inhibitors (ustekinumab, guselkumab, tildrakizumab, risankizumab), and IL17 inhibitors (secukinumab, ixekizumab, brodalumab) have verified these findings. Immune-related cells such as dendritic cells (DCs) and macrophages, in addition to Toll-like receptors and cytokines such as interferon (IFN)α, TNFα, IFNɤ, IL12, IL22, IL23, and IL17, are related to the pathogenesis of psoriasis. Here, we first review new insights regarding the pathogenesis of psoriasis, as it relates to DCs, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells. Based on these findings, we summarize currently available oral treatments and biologics. Furthermore, we describe a new treatment option including Janus kinase inhibitor, tyrosine kinase 2 inhibitor, modulator of sphingosine 1-phosphate receptor 1, and Rho-associated kinase 2 inhibitor. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 21207488 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/21/20/7488; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms21207488 |
| URL الوصول: | https://doaj.org/article/94cdf9c402da400eb5ed745fc566ea94 |
| رقم الأكسشن: | edsdoj.94cdf9c402da400eb5ed745fc566ea94 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21207488 14220067 16616596 |
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| DOI: | 10.3390/ijms21207488 |