دورية أكاديمية
Mild Effects of Sunscreen Agents on a Marine Flatfish: Oxidative Stress, Energetic Profiles, Neurotoxicity and Behaviour in Response to Titanium Dioxide Nanoparticles and Oxybenzone
| العنوان: | Mild Effects of Sunscreen Agents on a Marine Flatfish: Oxidative Stress, Energetic Profiles, Neurotoxicity and Behaviour in Response to Titanium Dioxide Nanoparticles and Oxybenzone |
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| المؤلفون: | Ana Carvalhais, Bárbara Pereira, Mariangela Sabato, Rafaela Seixas, Marina Dolbeth, Ana Marques, Sofia Guilherme, Patrícia Pereira, Mário Pacheco, Cláudia Mieiro |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 4, p 1567 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | UV filters, mixtures, marine fish, environmental concentrations, oxidative stress, bioenergetics, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | UV filters are potentially harmful to marine organisms. Given their worldwide dissemination and the scarcity of studies on marine fish, we evaluated the toxicity of an organic (oxybenzone) and an inorganic (titanium dioxide nanoparticles) UV filter, individually and in a binary mixture, in the turbot (Scophthalmus maximus). Fish were intraperitoneally injected and a multi-level assessment was carried out 3 and 7 days later. Oxybenzone and titanium dioxide nanoparticles induced mild effects on turbot, both isolated and in mixture. Neither oxidative stress (intestine, liver and kidney) nor neurotoxicity (brain) was found. However, liver metabolic function was altered after 7 days, suggesting the impairment of the aerobic metabolism. An increased motility rate in oxybenzone treatment was the only behavioural alteration (day 7). The intestine and liver were preferentially targeted, while kidney and brain were unaffected. Both infra- and supra-additive interactions were perceived, with a toxicodynamic nature, resulting either in favourable or unfavourable toxicological outcomes, which were markedly dependent on the organ, parameter and post-injection time. The combined exposure to the UV filters did not show a consistent increment in toxicity in comparison with the isolated exposures, which is an ecologically relevant finding providing key information towards the formulation of environmentally safe sunscreen products. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 22041567 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/4/1567; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms22041567 |
| URL الوصول: | https://doaj.org/article/975cd2723a8a4624956d27db04c3f9d3 |
| رقم الأكسشن: | edsdoj.975cd2723a8a4624956d27db04c3f9d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22041567 14220067 16616596 |
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| DOI: | 10.3390/ijms22041567 |