Introduction: The most awaited solution is an efficient COVID-19 vaccine. COVID-19 vaccine acceptance has not been studied in a meta-analysis. The objective of this research was to find the acceptance of COVID-19 vaccination and correlated variables. Methods: A systematic review of studies on acceptance of COVID-19 vaccination and correlated variables in the ProQuest, PubMed, and EBSCO to find relevant articles published between January 2020 and March 2021. Using fixed and random-effect models, the risk factors Pooled Odds Ratio (POR) were measured. The heterogeneity was calculated using the I-squared formula. Egger's and Begg's tests were utilised to determine publication bias. STATA 16.0 was used for all data processing and analysis. Results: This study results showed the related factors for COVID-19 vaccination acceptance, high income has the highest odd ratio (POR = 2.36), followed by encountered with COVID-19 (POR = 2.34), fear about COVID-19 (POR = 2.07), perceived benefits (POR = 1.81), flu vaccine during the previous season (POR = 1.69), healtcare workers (POR = 1.62), male (POR = 1.61), married (POR = 1.59), perceived risk (POR = 1.52), trust in health system (POR = 1.52), chronic diseases (POR = 1.47), high education (POR = 1.46), high level of knowledge (POR = 1.39), female (1.39), and older age (POR = 1.07). The heterogeneity calculation showed homogenous among studies in high income, fear about COVID-19, healthcare workers, married, chronic diseases, and female (I2 ≤ 50%). For the studies included in this review, there was no apparent publication bias. Conclusion: The analysis of this review may be useful to the nation in determining the best method for implementing COVID-19 mass vaccination programs based on relevant factors that influence vaccine acceptance.
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