دورية أكاديمية
Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study
| العنوان: | Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study |
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| المؤلفون: | Mei Mei, Hong-Wen Zhao, Qian-Guang Pan, You-Min Pu, Mao-Zhi Tang, Bing-Bing Shen |
| المصدر: | Journal of Investigative Surgery, Vol 31, Iss 1, Pp 14-23 (2018) |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | n-acetylcysteine, acute kidney injury/kidney injury, cardiac surgery/heart surgery, coronary artery bypass, creatinine, meta-analysis, Surgery, RD1-811 |
| الوصف: | Purpose: To evaluate whether perioperative N-acetylcysteine (NAC) administration reduces the risk of cardiac surgery associated acute kidney injury (CSA-AKI). Materials and Methods: A systematic literature review (Medline, PubMed, Cochrane, Biomedical central, Google Scholar) identified 10 studies (1391 patients; 695 NAC and 696 placebo) that compared the efficacy and adverse effects of perioperative NAC administration for CSA-AKI prevention in adults undergoing elective cardiac surgery. Meta-analysis was performed using Comprehensive Meta-Analysis statistical software. Results: Patients in the NAC-treated and placebo groups had similar rate of CSA-AKI occurrence, change in creatinine levels, as well as the in-hospital mortality rate (RR = 0.841, 95% CI = 0.691 to 1.023, p = 0.083; pooled difference in means = −0.328, 95% CI = −0.712 to 0.056, p = 0.094; RR = 0.741, 95% CI = 0.388 to 1.418, p = 0.366, respectively). Conclusions: Our study does not support perioperative NAC administration as a mean to reduce the risk of CSA-AKI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0894-1939 1521-0553 08941939 |
| Relation: | https://doaj.org/toc/0894-1939; https://doaj.org/toc/1521-0553 |
| DOI: | 10.1080/08941939.2016.1269853 |
| URL الوصول: | https://doaj.org/article/97be5dfa4903437b832ee99d21a653d3 |
| رقم الأكسشن: | edsdoj.97be5dfa4903437b832ee99d21a653d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 08941939 15210553 |
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| DOI: | 10.1080/08941939.2016.1269853 |