دورية أكاديمية
COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition
| العنوان: | COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition |
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| المؤلفون: | Shilin Zhao, Kris Y. W. Lok, Zhen Y. Sin, Ye Peng, Heidi S. L. Fan, Nitya Nagesh, Martha S. L. Choi, Jojo Y. Y. Kwok, Edmond P. H. Choi, Xi Zhang, Hogan Kok-Fung Wai, Leo C. H. Tsang, Samuel S. M. Cheng, Matthew K. L. Wong, Jie Zhu, Chris K. P. Mok, Siew C. Ng, Francis K. L. Chan, Malik Peiris, Leo L. M. Poon, Hein M. Tun |
| المصدر: | npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023) |
| بيانات النشر: | Nature Portfolio, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Newborns can acquire immunological protection to SARS-CoV-2 through vaccine-conferred antibodies in human breast milk. However, there are some concerns around lactating mothers with regards to potential short- and long-term adverse events and vaccine-induced changes to their breast milk microbiome composition, which helps shape the early-life microbiome. Thus, we sought to explore if SARS-CoV-2 mRNA vaccine could change breast milk microbiota and how the changes impact the levels of antibodies in breast milk. We recruited 49 lactating mothers from Hong Kong who received two doses of BNT162b2 vaccine between June 2021 and August 2021. Breast milk samples were self-collected by participants pre-vaccination, one week post-first dose, one week post-second dose, and one month post-second dose. The levels of SARS-CoV-2 spike-specific IgA and IgG in breast milk peaked at one week post-second dose. Subsequently, the levels of both antibodies rapidly waned in breast milk, with IgA levels returning to baseline levels one month post-second dose. The richness and composition of human breast milk microbiota changed dynamically throughout the vaccination regimen, but the abundances of beneficial microbes such as Bifidobacterium species did not significantly change after vaccination. Additionally, we found that baseline breast milk bacterial composition can predict spike-specific IgA levels at one week post-second dose (Area Under Curve: 0.72, 95% confidence interval: 0.58–0.85). Taken together, our results identified specific breast milk microbiota markers associated with high levels of IgA in the breast milk following BNT162b2 vaccine. Furthermore, in lactating mothers, BNT162b2 vaccines did not significantly reduce probiotic species in breast milk. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2059-0105 |
| Relation: | https://doaj.org/toc/2059-0105 |
| DOI: | 10.1038/s41541-023-00745-4 |
| URL الوصول: | https://doaj.org/article/97c98fea7c374c10952279eef846a51e |
| رقم الأكسشن: | edsdoj.97c98fea7c374c10952279eef846a51e |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20590105 |
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| DOI: | 10.1038/s41541-023-00745-4 |