دورية أكاديمية
Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn's disease.
العنوان: | Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn's disease. |
---|---|
المؤلفون: | Liesbeth Allais, Stephanie Verschuere, Tania Maes, Rebecca De Smet, Sarah Devriese, Gerard Bryan Gonzales, Harald Peeters, Koen Van Crombruggen, Claus Bachert, Martine De Vos, Guy G Brusselle, Ken R Bracke, Claude A Cuvelier, Debby Laukens |
المصدر: | PLoS ONE, Vol 15, Iss 8, p e0236657 (2020) |
بيانات النشر: | Public Library of Science (PLoS), 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | Crohn's disease is a pathological condition of the gastro-intestinal tract, causing severe transmural inflammation in the ileum and/or colon. Cigarette smoking is one of the best known environmental risk factors for the development of Crohn's disease. Nevertheless, very little is known about the effect of prolonged cigarette smoke exposure on inflammatory modulators in the gut. We examined the effect of cigarette smoke on cytokine profiles in the healthy and inflamed gut of human subjects and in the trinitrobenzene sulphonic acid mouse model, which mimics distal Crohn-like colitis. In addition, the effect of cigarette smoke on epithelial expression of transient receptor potential channels and their concurrent increase with cigarette smoke-augmented cytokine production was investigated. Active smoking was associated with increased IL-8 transcription in ileum of controls (p < 0,001; n = 18-20/group). In the ileum, TRPV1 mRNA levels were decreased in never smoking Crohn's disease patients compared to healthy subjects (p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0236657 |
URL الوصول: | https://doaj.org/article/9ad2992fc28a4bdbb4e918beb15bfd61 |
رقم الأكسشن: | edsdoj.9ad2992fc28a4bdbb4e918beb15bfd61 |
قاعدة البيانات: | Directory of Open Access Journals |
كن أول من يترك تعليقا!