دورية أكاديمية
Evaluation of prevalence of weak D antigen among rhesus-negative patients in tertiary care hospitals in Bangladesh: A multicenter study
| العنوان: | Evaluation of prevalence of weak D antigen among rhesus-negative patients in tertiary care hospitals in Bangladesh: A multicenter study |
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| المؤلفون: | Tamanna Afroz, Manjuma Rahman, Bepasha Naznin, Md Ashadul Islam, Abu Jafar Mohammed Saleh |
| المصدر: | Global Journal of Transfusion Medicine, Vol 6, Iss 2, Pp 146-149 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | bangladesh, d antigen, rh negative, weak d antigen, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | Background and Objectives: In 1939, D antigen was discovered which is believed to be the most immunogenic antigen in Rhesus (Rh) blood group system. There are some D variants such as weak D, partial D, and DEL due to gene polymorphism. These variants can cause RhD-positive person to behave like RhD negative which could result in alloimmunization. Clinically weak D antigen is very important due to its strong immunogenicity in spite of its low frequency. Hence, we need to know the prevalence of weak D variants in the community. The purpose of this study is to find out weak D prevalence among the Bangladeshi population. Methods: It is a retrospective study done over the last 5 years, from January 2015 to December 2019, at the department of transfusion medicine of three tertiary care hospitals in Bangladesh. A total of 177,702 patients were enrolled in the study. Blood samples that were negative for RhD were tested for weak D by indirect antiglobulin test according to institutional protocol. Results: Out of 177,702 patients, 7359 (4.1%) were found to be RhD negative and among those, 14 (0.19%) were weak D antigen positive. Conclusion: Weak D antigen is prevalent in Bangladesh and every RhD-negative individual should be checked for the presence of weak D to prevent RhD alloimmunization. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2468-8398 2455-8893 |
| Relation: | http://www.gjtmonline.com/article.asp?issn=2468-8398;year=2021;volume=6;issue=2;spage=146;epage=149;aulast=Afroz; https://doaj.org/toc/2468-8398; https://doaj.org/toc/2455-8893 |
| DOI: | 10.4103/gjtm.gjtm_118_20 |
| URL الوصول: | https://doaj.org/article/9b301811365b4ac5b7f993f4f17eb6fe |
| رقم الأكسشن: | edsdoj.9b301811365b4ac5b7f993f4f17eb6fe |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24688398 24558893 |
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| DOI: | 10.4103/gjtm.gjtm_118_20 |