دورية أكاديمية
Could COVID-19 Be a Hemoglobinopathy?
| العنوان: | Could COVID-19 Be a Hemoglobinopathy? |
|---|---|
| المؤلفون: | Tania Ahmed Shakoori, Muhammad Mansoor Hafeez, Arif Malik |
| المصدر: | Acta Clinica Croatica, Vol 59., Iss 4., Pp 740-744 (2020) |
| بيانات النشر: | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | COVID-19, High altitude pulmonary embolism, High altitude pulmonary edema, pathophysiology, Acute respiratory distress syndrome, CD147, Medicine |
| الوصف: | The world is struggling to deal with the corona pandemic. Effective therapies are still awaited due to the lack of understanding of the pathophysiological mechanism of the disease. Bearing recent research and clinical observations in mind, the authors propose a novel physiological mechanism of COVID-19 and explain development of COVID-19 related acute respiratory distress syndrome (ARDS) secondary to COVID-19 related hemoglobinopathy. It is a consistent observation that the radiological picture of COVID-19 related ARDS bears more resemblance to high altitude pulmonary edema (HAPE) than typical ARDS. There has been great controversy regarding this proposed similarity. The main argument from those objecting to this comparison is that the etiology is hypoxia in case of HAPE and inflammation in COVID-19 related ARDS. We propose that considering the recent bioinformatics prediction models, COVID-19 might first infect red blood cells via CD147 and cause hemoglobin damage. The resulting hypoxemia may cause pulmonary hypoxic vasoconstriction leading to HAPE-like lung lesions. The now introduced alveolar hypoxia further exaggerates hemoglobinopathy hypoxemia leading to a vicious cycle. In this review, the authors recommend laboratory experiments to prove these hypotheses. The proposed physiological mechanism has significant therapeutic implications. If proven, the authors suggest the use of exchange transfusion as adjunct therapy and development of anti-CD147 drugs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0353-9466 1333-9451 |
| Relation: | https://hrcak.srce.hr/file/370394; https://doaj.org/toc/0353-9466; https://doaj.org/toc/1333-9451 |
| DOI: | 10.20471/acc.2020.59.04.21 |
| URL الوصول: | https://doaj.org/article/9b524473871243159f9a48c0fdb139be |
| رقم الأكسشن: | edsdoj.9b524473871243159f9a48c0fdb139be |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03539466 13339451 |
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| DOI: | 10.20471/acc.2020.59.04.21 |