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Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering

التفاصيل البيبلوغرافية
العنوان: Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering
المؤلفون: Jiawen Si, Jiewen Dai, Jianjun Zhang, Sha Liu, Jing Gu, Jun Shi, Steve G. F. Shen, Lihe Guo
المصدر: Stem Cells International, Vol 2015 (2015)
بيانات النشر: Wiley, 2015.
سنة النشر: 2015
المجموعة: LCC:Internal medicine
مصطلحات موضوعية: Internal medicine, RC31-1245
الوصف: Emerging evidence suggests amniotic epithelial cells (AECs) as a promising source of progenitor cells in regenerative medicine and bone tissue engineering. However, investigations comparing the regenerative properties of AECs with other sources of stem cells are particularly needed before the feasibility of AECs in bone tissue engineering can be determined. This study aimed to compare human amniotic epithelial cells (hAECs), human bone marrow mesenchymal stem cells (hBMSCs), and human amniotic fluid derived mesenchymal stem cells (hAFMSCs) in terms of their morphology, proliferation, immunophenotype profile, and osteogenic capacity in vitro and in vivo. Not only greatly distinguished by cell morphology and proliferation, hAECs, hAFMSCs, and hBMSCs exhibited remarkably different signature regarding immunophenotypical profile. Microarray analysis revealed a different expression profile of genes involved in ossification along the three cell sources, highlighting the impact of different anatomical origin and molecular response to osteogenic induction on the final tissue-forming potential. Furthermore, our data indicated a potential role of FOXC2 in early osteogenic commitment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-966X
1687-9678
Relation: https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678
DOI: 10.1155/2015/565732
URL الوصول: https://doaj.org/article/e9c95266a7e94d65a59b0a75ff4e2f28
رقم الأكسشن: edsdoj.9c95266a7e94d65a59b0a75ff4e2f28
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1687966X
16879678
DOI:10.1155/2015/565732