دورية أكاديمية
Effect of hyperthermia on improving neutrophil restoration after intraperitoneal chemotherapy
| العنوان: | Effect of hyperthermia on improving neutrophil restoration after intraperitoneal chemotherapy |
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| المؤلفون: | Wan-Chun Huang, Chao-Chih Wu, Yun-Ting Hsu, Chih-Long Chang |
| المصدر: | International Journal of Hyperthermia, Vol 36, Iss 1, Pp 1254-1262 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medical technology |
| مصطلحات موضوعية: | bone marrow recovery, hipec, hyperthermic intraperitoneal chemotherapy, hyperthermia, neutrophil restoration, Medical technology, R855-855.5 |
| الوصف: | Purpose: Intraperitoneal (IP) chemotherapy has several benefits but also can have severe hematologic side effects. We compared the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) and conventional IP chemotherapy on bone marrow suppression and evaluated whether HIPEC increased neutrophil recovery. Methods: HIPEC or IP chemotherapy was administered to ovarian cancer–bearing mice. Bone marrow progenitor cell colony-forming unit (CFU) count, serum cytokine levels, and peripheral leukocyte count after HIPEC and IP chemotherapy were compared. Results: Peripheral neutrophil count, cytokine (G-CSF and CXCL1/KC) levels, and bone marrow progenitor cell CFU count were significantly higher after HIPEC than after IP chemotherapy. Conclusions: Hyperthermia increased the serum neutrophil-recruiting cytokine levels and reduced the magnitude of chemotherapy-induced neutropenia. Thus, HIPEC improved neutrophil and bone marrow recovery compared with conventional IP chemotherapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0265-6736 1464-5157 02656736 |
| Relation: | https://doaj.org/toc/0265-6736; https://doaj.org/toc/1464-5157 |
| DOI: | 10.1080/02656736.2019.1699172 |
| URL الوصول: | https://doaj.org/article/9e9a0049ad1342258b45e74171d4dd1d |
| رقم الأكسشن: | edsdoj.9e9a0049ad1342258b45e74171d4dd1d |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 02656736 14645157 |
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| DOI: | 10.1080/02656736.2019.1699172 |