دورية أكاديمية
Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience
| العنوان: | Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience |
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| المؤلفون: | Enas El Nadi, Mariam Elsherif, Madeeha Elwakeel, Hala Taha, Maged Elshafiey, Gehad Ahmed, Mohamed Zagloul, Dina Elgalaly, Elham Khaled, Sahar Ahmed |
| المصدر: | Research in Oncology, Vol 18, Iss 1, Pp 10-18 (2022) |
| بيانات النشر: | Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | clear cell adenocarcinoma, germ cell tumor, pediatric, rhabdomyosarcoma, vagina, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: Primary vaginal malignancies are rare in children. Their management has evolved during the last decades from radical surgery to neoadjuvant chemotherapy followed by local control with conservative surgery or radiotherapy. Aim: To describe the presentation, management, and outcome of pediatric vaginal malignancies. Methods: Retrospective review of the medical records of children with 1ry vaginal malignancies who had been treated at the Children’s Cancer Hospital Egypt (CCHE)-57357 from June 2007 till December 2018. Results: During the 11 years, 34 pediatric patients with 1ry vaginal malignancies were identified. The histopathology was rhabdomyosarcoma (RMS) in 19 (55.9%) patients, germ cell tumor (GCT) in 13 (38.2%), and clear cell adenocarcinoma (CCA) in two (5.9%). Vaginal bleeding was the presenting symptom in 65% of the patients. The 5-year overall survival and event-free survival rates were 73.7% and 77.8%, respectively, in RMS patients. In GCT patients, the 5-year overall survival and event-free survival rates were 84.6% and 61.5%, respectively. One of the two CCA patients died because of disease progression and the other was alive with progressive disease. Conclusions: Primary vaginal tumors are rare in children and generally have a good prognosis. Treatment with chemotherapy only or with either conservative surgery or radiotherapy may achieve an excellent outcome in pediatric primary vaginal RMS and GCT. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2357-0687 2357-0695 |
| Relation: | https://resoncol.journals.ekb.eg/article_246931_c736f1eadaf57388d62e93fd7c2e7387.pdf; https://doaj.org/toc/2357-0687; https://doaj.org/toc/2357-0695 |
| DOI: | 10.21608/resoncol.2021.73214.1142 |
| URL الوصول: | https://doaj.org/article/9f517a054ccc4c1491b71f50c1a4f337 |
| رقم الأكسشن: | edsdoj.9f517a054ccc4c1491b71f50c1a4f337 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23570687 23570695 |
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| DOI: | 10.21608/resoncol.2021.73214.1142 |