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The different course of alcoholic and idiopathic chronic pancreatitis: A long-term study of 2,037 patients.

التفاصيل البيبلوغرافية
العنوان: The different course of alcoholic and idiopathic chronic pancreatitis: A long-term study of 2,037 patients.
المؤلفون: Lu Hao, Li-Sheng Wang, Yu Liu, Teng Wang, Hong-Lei Guo, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Lei Xin, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Xiang-Peng Zeng, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhuan Liao, Zhi-Jie Cong, Zheng-Lei Xu, Zhao-Shen Li, Liang-Hao Hu
المصدر: PLoS ONE, Vol 13, Iss 6, p e0198365 (2018)
بيانات النشر: Public Library of Science (PLoS), 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BackgroundChronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare the natural course of alcoholic chronic pancreatitis (ACP) and idiopathic chronic pancreatitis (ICP).MethodsCP patients admitted to our center from January 2000 to December 2013 were enrolled. Characteristics were compared between ACP and ICP patients. Cumulative rates of diabetes mellitus (DM), steatorrhea, pancreatic stone, pancreatic pseudocyst, biliary stricture, and pancreatic cancer after the onset and the diagnosis of CP were calculated, respectively. The cumulative rates of DM and steatorrhea after diagnosis of pancreatic stone were also calculated.ResultsA total of 2,037 patients were enrolled. Among them, 19.8% (404/2,037) were ACP and 80.2% (1,633/2,037) were ICP patients. ACP and ICP differs in many aspects, especially in gender, age, smoking, complications, morphology of pancreatic duct, and type of pain. The development of DM, steatorrhea, PPC, pancreatic stone, and biliary stricture were significantly earlier and more common in ACP patients. No significant difference was observed for pancreatic cancer development. There was a rather close correlation between exocrine/endocrine insufficiency and pancreatic stone in ACP patients, which was much less correlated in ICP patients.ConclusionThe long-term profile of ACP and ICP differs in some important aspects. ACP patients usually have a more severe course of CP. These differences should be recognized in the diagnosis and treatment of CP.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0198365
URL الوصول: https://doaj.org/article/d9fb74e0689347f990a5c450eb6eac7b
رقم الأكسشن: edsdoj.9fb74e0689347f990a5c450eb6eac7b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0198365