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Quantitative evaluation of emphysema for predicting immunotherapy response in patients with advanced non-small-cell lung cancer

التفاصيل البيبلوغرافية
العنوان: Quantitative evaluation of emphysema for predicting immunotherapy response in patients with advanced non-small-cell lung cancer
المؤلفون: Yoshimi Noda, Takayuki Shiroyama, Kentaro Masuhiro, Saori Amiya, Takatoshi Enomoto, Yuichi Adachi, Reina Hara, Takayuki Niitsu, Yujiro Naito, Kotaro Miyake, Shohei Koyama, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract The efficacy of immune checkpoint inhibitors (ICIs) in patients with advanced non-small-cell lung cancer (NSCLC) might depend on the presence of emphysema, but this association is not established. We aimed to investigate if quantitively and automatically measuring emphysema can predict the effect of ICIs. We retrospectively analyzed 56 patients with NSCLC who underwent immunotherapy at our hospital. We used the Goddard scoring system (GS) to evaluate the severity of emphysema on baseline CT scans using three-dimensional image analysis software. The emphysema group (GS ≥ 1) showed better progression-free survival (PFS) than the non-emphysema group (GS = 0) (6.5 vs. 2.3 months, respectively, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-022-13131-2
URL الوصول: https://doaj.org/article/9fc0e43a948544a1b161ff14baf2d467
رقم الأكسشن: edsdoj.9fc0e43a948544a1b161ff14baf2d467
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-022-13131-2