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Peroxisomal-PEX5 Controls Fasting-Induced Lipolysis

التفاصيل البيبلوغرافية
العنوان: Peroxisomal-PEX5 Controls Fasting-Induced Lipolysis
المؤلفون: Ji Seul Han, Kyung Hee Han, Jae Bum Kim
المصدر: Contact, Vol 3 (2020)
بيانات النشر: SAGE Publishing, 2020.
سنة النشر: 2020
المجموعة: LCC:Biology (General)
LCC:Biochemistry
مصطلحات موضوعية: Biology (General), QH301-705.5, Biochemistry, QD415-436
الوصف: Lipid droplets (LDs) are dynamic subcellular organelles which play critical roles for lipid homeostasis upon change of nutritional state. Although several organelles such as mitochondria and peroxisomes are involved in lipid metabolism, physiological roles and mediators involved in the spatiotemporal regulation of these subcellular organelles for energy metabolism has largely remained elusive. Our recent study implicates the importance of peroxisomes in the translocation of lipases onto LDs upon fasting cues. Also, we found that peroxisomal protein PEX5 modulates PKA-induced lipolysis by escorting ATGL toward LDs. This is accompanied by KIFC3-mediated migration of peroxisomes, leading to the physical contact between peroxisomes and LDs. In adipocyte-specific PEX5-knockout mice, fasting induced lipolysis is attenuated due to defective ATGL recruitment onto LDs. These results show that PEX5 plays a pivotal role in PKA induced lipolysis that occurs upon nutritional deprivation. We further speculate that the contact between LDs and peroxisomes could facilitate lipid metabolism via exchange of lipid metabolites between the organelles in response to nutritional changes.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2515-2564
25152564
Relation: https://doaj.org/toc/2515-2564
DOI: 10.1177/2515256420960303
URL الوصول: https://doaj.org/article/eb0424589e174de5af6abc9d03743e15
رقم الأكسشن: edsdoj.b0424589e174de5af6abc9d03743e15
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:25152564
DOI:10.1177/2515256420960303