التفاصيل البيبلوغرافية
العنوان:
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer
المؤلفون:
Pauliina M. Munne , Lahja Martikainen , Iiris Räty , Kia Bertula , Nonappa , Janika Ruuska , Hanna Ala-Hongisto , Aino Peura , Babette Hollmann , Lilya Euro , Kerim Yavuz , Linda Patrikainen , Maria Salmela , Juho Pokki , Mikko Kivento , Juho Väänänen , Tomi Suomi , Liina Nevalaita , Minna Mutka , Panu Kovanen , Marjut Leidenius , Tuomo Meretoja , Katja Hukkinen , Outi Monni , Jeroen Pouwels , Biswajyoti Sahu , Johanna Mattson , Heikki Joensuu , Päivi Heikkilä , Laura L. Elo , Ciara Metcalfe , Melissa R. Junttila , Olli Ikkala , Juha Klefström
المصدر:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
بيانات النشر:
Nature Portfolio, 2021.
سنة النشر:
2021
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is regulated by matrix stiffness via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-021-27220-9
URL الوصول:
https://doaj.org/article/b09c6053c2ba40338196b223c9534247
رقم الأكسشن:
edsdoj.b09c6053c2ba40338196b223c9534247
قاعدة البيانات:
Directory of Open Access Journals
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