دورية أكاديمية
Metabolic syndrome components and vitamin D availability relationship in late postmenopausal women
| العنوان: | Metabolic syndrome components and vitamin D availability relationship in late postmenopausal women |
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| المؤلفون: | N. V. Izmozherova, A. A. Popov, A. V. Ryabinina, A. A. Vikhareva, E. A. Safianik, A. V. Spevak, M. A. Shambatov, V. M. Bakhtin |
| المصدر: | Ожирение и метаболизм, Vol 20, Iss 1, Pp 4-12 (2023) |
| بيانات النشر: | Endocrinology Research Centre, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Physiology LCC:Biochemistry |
| مصطلحات موضوعية: | vitamin d deficiency, metabolic syndrome, abdominal obesity, hypertension, hyperglycemia, dyslipidemias, postmenopause, Physiology, QP1-981, Biochemistry, QD415-436 |
| الوصف: | BACKGROUND: The global prevalence of vitamin D deficiency is currently a real threat due to association with major chronic non-communicable diseases. Abdominal obesity, hypertension, dyslipidemia, and hyperglycemia contribute significantly to cardiometabolic risk in late postmenopausal women.AIM: to assess the frequency of deficiency and insufficiency of 25(OH)D in late postmenopausal residents of Yekaterinburg; to establish associations of 25(OH)D serum concentration with components of metabolic syndrome and severity of menopausal symptoms.MATERIALS AND METHODS: During the period from October 2018 to March 2020 145 independently living late postmenopausal residents of Yekaterinburg were enrolled in a cross-sectional study. The following scope of data regarding each of the subjects was collected: complaints and anamnesis, anthropometry, diagnosis of metabolic syndrome, arterial hypertension and diabetes mellitus, assessment of 25 (OH)D level by the ECLIA method, LDL-C, HDL-C levels, serum TG by the enzymatic colorimetric method, as well as the evaluation of the modified menopausal index.RESULTS: Adequate serum level of 25(OH)D was detected in 20.6% patients, insufficiency and deficiency were found in 33.1 and 46.2% cases, respectively. In patients with vitamin D deficiency and insufficiency, the most frequent metabolic syndrome components were arterial hypertension (p=0.02; OR 3.5; CI 1.2–10.6) and abdominal obesity (p=0.03; OR 2.8; CI 1.1–7.2). Vitamin D deficient subjects had significantly lower serum HDL and increased TG levels (p=0.04), compared to the adequately provided 25(OH)D patients. Vitamin D levels were not associated with the severity of menopausal symptoms in late postmenopausal women. Regular daily intake of 400–2000 IU of colecalciferol contributed to higher serum 25(OH)D level.CONCLUSION: a high prevalence of vitamin D deficiency among postmenopausal women of Yekaterinburg was detected. Diagnosis and correction of vitamin D levels are necessary for timely reduction of cardiometabolic risk, primarily due to the potential pleiotropic effects of D-hormone on the renin-angiotensin-aldosterone system, carbohydrate and lipid metabolism. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 2071-8713 2306-5524 |
| Relation: | https://www.omet-endojournals.ru/jour/article/view/12991; https://doaj.org/toc/2071-8713; https://doaj.org/toc/2306-5524 |
| DOI: | 10.14341/omet12737 |
| URL الوصول: | https://doaj.org/article/b16c4237a2bf49f48306817e828fe817 |
| رقم الأكسشن: | edsdoj.b16c4237a2bf49f48306817e828fe817 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20718713 23065524 |
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| DOI: | 10.14341/omet12737 |