دورية أكاديمية
Intriguing findings of liver fibrosis following COVID-19
العنوان: | Intriguing findings of liver fibrosis following COVID-19 |
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المؤلفون: | Oksana Kolesova, Ieva Vanaga, Sniedze Laivacuma, Aleksejs Derovs, Aleksandrs Kolesovs, Maija Radzina, Ardis Platkajis, Jelena Eglite, Elvira Hagina, Seda Arutjunana, Davis Simanis Putrins, Jelena Storozenko, Baiba Rozentale, Ludmila Viksna |
المصدر: | BMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021) |
بيانات النشر: | BMC, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
مصطلحات موضوعية: | Serological biomarker, COVID-19, Hyaluronic acid, Liver fibrosis index, Consequences, Diseases of the digestive system. Gastroenterology, RC799-869 |
الوصف: | Abstract Background Studies on a new coronavirus disease (COVID-19) show the elevation of liver enzymes and liver fibrosis index (FIB-4) independently on pre-existing liver diseases. It points to increased liver fibrogenesis during acute COVID-19 with possible long-term consequences. This study aimed to assess liver fibrosis in COVID-19 patients by serum hyaluronic acid (HA) and FIB-4. Methods The study included the acute COVID-19 group (66 patients, 50% females, mean age 58.3 ± 14.6), the post-COVID group (58 patients in 3–6 months after the recovery, 47% females, mean age 41.2 ± 13.4), and a control group (17 people, 47% females, mean age 42.8 ± 11.0). Ultrasound elastography was performed in the post-COVID and control groups. Results Sixty-five percent of the acute COVID-19 group had increased FIB-4 (> 1.45), and 38% of patients had FIB-4 ≥ 3.25. After matching by demographics, 52% of acute COVID-19 and 5% of the post-COVID group had FIB-4 > 1.45, and 29% and 2% of patients had FIB-4 ≥ 3.25, respectively. Increased serum HA (≥ 75 ng/ml) was observed in 54% of the acute COVID-19 and 15% of the post-COVID group. In the acute COVID-19 group, HA positively correlated with FIB-4, AST, ALT, LDH, IL-6, and ferritin and negatively with blood oxygen saturation. In the post-COVID group, HA did not correlate with FIB-4, but it was positively associated with higher liver stiffness and ALT. Conclusion More than half of acute COVID-19 patients had increased serum HA and FIB-4 related to liver function tests, inflammatory markers, and blood oxygen saturation. It provides evidence for the induction of liver fibrosis by multiple factors during acute COVID-19. Findings also indicate possible liver fibrosis in about 5% of the post-COVID group. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1471-230X |
Relation: | https://doaj.org/toc/1471-230X |
DOI: | 10.1186/s12876-021-01939-7 |
URL الوصول: | https://doaj.org/article/deb19ca2150a46a19f1d57372c4f13ba |
رقم الأكسشن: | edsdoj.b19ca2150a46a19f1d57372c4f13ba |
قاعدة البيانات: | Directory of Open Access Journals |
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