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Astrocyte-Derived Exosomes Differentially Shape T Cells’ Immune Response in MS Patients

التفاصيل البيبلوغرافية
العنوان: Astrocyte-Derived Exosomes Differentially Shape T Cells’ Immune Response in MS Patients
المؤلفون: Piotr Szpakowski, Dominika Ksiazek-Winiarek, Joanna Czpakowska, Mateusz Kaluza, Marta Milewska-Jedrzejczak, Andrzej Glabinski
المصدر: International Journal of Molecular Sciences, Vol 24, Iss 8, p 7470 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: astrocytes, exosomes, multiple sclerosis, T-cells, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Astrocytes, the most abundant group of glia cells in the brain, provide support for neurons and indicate multiple various functions in the central nervous system (CNS). Growing data additionally describe their role in the regulation of immune system activity. They exert their function not only by direct contact with other cell types, but also through an indirect method, e.g., by secreting various molecules. One such structure is extracellular vesicles, which are important mediators of crosstalk between cells. In our study, we observed that the impact of exosomes derived from astrocytes with various functional phenotype differently affect the immune response of CD4+ T cells, both from healthy individuals and from patients with multiple sclerosis (MS). Astrocytes, by modulating exosome cargo, impacts the release of IFN-γ, IL-17A and CCL2 in our experimental conditions. Considering the proteins concentration in cell culture supernatants and the cellular percentage of Th phenotypes, it could be stated that human astrocytes, by the release of exosomes, are able to modify the activity of human T cells.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/24/8/7470; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms24087470
URL الوصول: https://doaj.org/article/b27783a78c5f4619b60f9830cf274fa4
رقم الأكسشن: edsdoj.b27783a78c5f4619b60f9830cf274fa4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms24087470