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Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells

التفاصيل البيبلوغرافية
العنوان: Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells
المؤلفون: Soo-Jeung Park, Minhee Lee, Ki-Young Kim, Su Shin, Min-Woo Choi, Eun-Jin Hong, Jeongmin Lee
المصدر: Applied Sciences, Vol 12, Iss 1, p 290 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Technology
LCC:Engineering (General). Civil engineering (General)
LCC:Biology (General)
LCC:Physics
LCC:Chemistry
مصطلحات موضوعية: Trapa japonica Flerov, adipogenesis, lipogenesis, lipolysis, 3T3-L1, anti-obesity, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
الوصف: Our study investigated that the anti-obesity effect of the Trapa japonica Flerov extract (TJ) in differentiated 3T3-L1 adipocytes. To this end, 3T3-L1 cells were treated with TJ during their differentiation period. On the last day of the cell culture, we tested intracellular cAMP, FA, glycerol release, TG, and performed Oil Red O staining and Western blot assays. On the part of adipogenesis, lipogenesis, and lipolysis mechanism, TJ increased the cAMP (maximum 125.4%) levels and glycerol release (maximum four times) and decreased FA (maximum 35.1%) and TG (maximum 35.7%) levels. Furthermore, the protein expression levels of each mechanism-related factor were regulated in a dose-dependent manner. These results indicate that TJ reduced lipid accumulation by max 53.6% and 47.9%, respectively, in adipogenesis and lipolysis mechanisms. We expect this effect of TJ to be due to its component, ellagic acid. In conclusion, we found that TJ inhibits TG synthesis during adipogenesis and lipogenesis, promotes lipolysis, and thus, indicating its potential as a functional food for obesity prevention.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-3417
Relation: https://www.mdpi.com/2076-3417/12/1/290; https://doaj.org/toc/2076-3417
DOI: 10.3390/app12010290
URL الوصول: https://doaj.org/article/b2f1743df6434552a3ab54ea7885a4f5
رقم الأكسشن: edsdoj.b2f1743df6434552a3ab54ea7885a4f5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20763417
DOI:10.3390/app12010290