دورية أكاديمية
Potential of Titanium Pins Coated with Fibroblast Growth Factor-2–Calcium Phosphate Composite Layers to Reduce the Risk of Impaired Bone–Pin Interface Strength in the External Fixation of Distal Radius Fractures
العنوان: | Potential of Titanium Pins Coated with Fibroblast Growth Factor-2–Calcium Phosphate Composite Layers to Reduce the Risk of Impaired Bone–Pin Interface Strength in the External Fixation of Distal Radius Fractures |
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المؤلفون: | Hirotaka Mutsuzaki, Yohei Yanagisawa, Hiroshi Noguchi, Atsuo Ito, Masashi Yamazaki |
المصدر: | Journal of Clinical Medicine, Vol 13, Iss 11, p 3040 (2024) |
بيانات النشر: | MDPI AG, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | fibroblast growth factor-2 (FGF-2), calcium phosphate, coating, external fixation, distal radius fractures, impaired bone fixation, Medicine |
الوصف: | Background: The risk of impaired bone–pin interface strength in titanium (Ti) pins coated with fibroblast growth factor (FGF)–calcium phosphate (CP) composite layers is yet to be evaluated in a clinical study. This retrospective study used Weibull plot analysis to evaluate bone–pin interface strength in Ti pins coated with FGF-CP layers for external distal radius fracture fixation. Methods: The distal radial fractures were treated with external fixation. The FGF-CP group comprised five patients (all women, aged 70.4 ± 5.9 (range: 62–77) years), and the uncoated pin group comprised ten patients (eight women and two men, aged 64.4 ± 11.7 (range: 43–83) years). The pins were removed after six weeks. The insertion and extraction peak torques were measured. The extraction peak torque was evaluated using Weibull plot analysis. Results: We compared the extraction torque of the two groups at or below 506 Nmm for a fair comparison using Weibull plot analysis. The Weibull plots were linear for both the FGF-CP and uncoated pin groups. The slope of the regression line was significantly higher in the FGF-CP group (1.7343) than in the uncoated pin group (1.5670) (p = 0.011). The intercept of the regression line was significantly lower in the FGF-CP group (−9.847) than in the uncoated pin group (−8.708) (p = 0.002). Thus, the two regression lines significantly differed. Conclusions: Ti pins coated with FGF-CP layers exhibit the potential to reduce the risk of impaired bone–pin interface strength in the external fixation of distal radius fractures. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2077-0383 |
Relation: | https://www.mdpi.com/2077-0383/13/11/3040; https://doaj.org/toc/2077-0383 |
DOI: | 10.3390/jcm13113040 |
URL الوصول: | https://doaj.org/article/b35876f1011348c99ae66cde67e4bc63 |
رقم الأكسشن: | edsdoj.b35876f1011348c99ae66cde67e4bc63 |
قاعدة البيانات: | Directory of Open Access Journals |
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