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MRI‐based risk stratification for recurrent ischemic stroke in embolic stroke of undetermined source

التفاصيل البيبلوغرافية
العنوان: MRI‐based risk stratification for recurrent ischemic stroke in embolic stroke of undetermined source
المؤلفون: Quan‐Ying Liu, Ying‐Jie Dai, Xiao‐Qiu Li, Xin‐Hong Wang, George Ntaios, Hui‐Sheng Chen
المصدر: Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1533-1543 (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
الوصف: Abstract Objective Leukoaraiosis and other brain MRI‐assessed parameters were shown to be associated with recurrent stroke in this population. We aimed to develop an MRI‐based predictive tool for risk stratification of ESUS patients. Methods We retrospectively assessed consecutive patients who were diagnosed with ESUS and underwent brain MRI and performed a multivariable analysis with the outcome of recurrent stroke/TIA. Based on the coefficient of each covariate, we generated an integer‐based point scoring system. The discrimination and calibration of the score were assessed using the area under the receiver operator characteristic curve, net reclassification improvement, integrated discrimination improvement, calibration curve, and decision curve analysis. Also, we compared the new score with a previously published score (ALM score). Results Among 176 patients followed for an overall period of 902.3 patient‐years (median of 74 months), there were 39 recurrent ischemic stroke/TIAs (4.32 per 100 patient‐years). Fazekas score (HR: 1.26, 95% CI: 1.03–1.54), enlarged perivascular space (EPVS) (HR: 2.76, 95% CI: 1.12–6.17), NIHSS at admission (HR: 1.11, 95% CI: 1.02–1.18), and infarct subtypes (HR: 2.88, 95% CI: 1.34–6.17) were associated with recurrent stroke/TIA. Accordingly, a score (FENS score) was developed with AUC‐ROC values of 0.863, 0.788, and 0.858 for 1, 3, and 5 years, respectively. These were significantly better than the AUC‐ROC of ALM score (0.635, 0.695, and 0.705, respectively). The FENS score exhibited better calibration and discrimination ability than the ALM score (Hosmer–Lemeshow test χ2: 4.402, p = 0.819). Conclusion The MRI‐based FENS score can provide excellent predictive performance for recurrent stroke/TIA and may assist in risk stratification of ESUS patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2328-9503
Relation: https://doaj.org/toc/2328-9503
DOI: 10.1002/acn3.51843
URL الوصول: https://doaj.org/article/b6c28d68d7ab4135aee6fcc0e2f9ea18
رقم الأكسشن: edsdoj.b6c28d68d7ab4135aee6fcc0e2f9ea18
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23289503
DOI:10.1002/acn3.51843