دورية أكاديمية
Serum metabolic profile and metabolome genome-wide association study in chicken
| العنوان: | Serum metabolic profile and metabolome genome-wide association study in chicken |
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| المؤلفون: | Jing Tian, Xiaoning Zhu, Hanyu Wu, Yuzhe Wang, Xiaoxiang Hu |
| المصدر: | Journal of Animal Science and Biotechnology, Vol 14, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Animal culture LCC:Veterinary medicine |
| مصطلحات موضوعية: | Chicken, Metabolic traits, mGWAS, Serum, Animal culture, SF1-1100, Veterinary medicine, SF600-1100 |
| الوصف: | Abstract Background Chickens provide globally important livestock products. Understanding the genetic and molecular mechanisms underpinning chicken economic traits is crucial for improving their selective breeding. Influenced by a combination of genetic and environmental factors, metabolites are the ultimate expression of physiological processes and can provide key insights into livestock economic traits. However, the serum metabolite profile and genetic architecture of the metabolome in chickens have not been well studied. Results Here, comprehensive metabolome detection was performed using non-targeted LC–MS/MS on serum from a chicken advanced intercross line (AIL). In total, 7,191 metabolites were used to construct a chicken serum metabolomics dataset and to comprehensively characterize the serum metabolism of the chicken AIL population. Regulatory loci affecting metabolites were identified in a metabolome genome-wide association study (mGWAS). There were 10,061 significant SNPs associated with 253 metabolites that were widely distributed across the entire chicken genome. Many functional genes affect metabolite synthesis, metabolism, and regulation. We highlight the key roles of TDH and AASS in amino acids, and ABCB1 and CD36 in lipids. Conclusions We constructed a chicken serum metabolite dataset containing 7,191 metabolites to provide a reference for future chicken metabolome characterization work. Meanwhile, we used mGWAS to analyze the genetic basis of chicken metabolic traits and metabolites and to improve chicken breeding. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2049-1891 |
| Relation: | https://doaj.org/toc/2049-1891 |
| DOI: | 10.1186/s40104-023-00868-7 |
| URL الوصول: | https://doaj.org/article/dab8b14f84ef4311a47938bc714b40fd |
| رقم الأكسشن: | edsdoj.b8b14f84ef4311a47938bc714b40fd |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20491891 |
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| DOI: | 10.1186/s40104-023-00868-7 |