دورية أكاديمية
Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies
| العنوان: | Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies |
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| المؤلفون: | Juno Kim, Hye Soo Chung, Min-Kyu Choi, Yong Kyun Roh, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Jae Myung Yu, Shinje Moon |
| المصدر: | Diabetes & Metabolism Journal, Vol 43, Iss 4, Pp 447-460 (2019) |
| بيانات النشر: | Korean Diabetes Association, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | antioxidants, diabetes mellitus, selenium, trace elements, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | BackgroundEpidemiological studies have suggested an association between selenium (Se) and diabetes mellitus (DM). However, different studies have reported conflicting results. Therefore, we performed a comprehensive meta-analysis to clarify the impact of Se on DM.MethodsWe searched the PubMed database for studies on the association between Se and DM from inception to June 2018.ResultsTwenty articles evaluating 47,930 participants were included in the analysis. The meta-analysis found that high levels of Se were significantly associated with the presence of DM (pooled odds ratios [ORs], 1.88; 95% confidence interval [CI], 1.44 to 2.45). However, significant heterogeneity was found (I2=82%). Subgroup analyses were performed based on the Se measurement methods used in each study. A significant association was found between high Se levels and the presence of DM in the studies that used blood (OR, 2.17; 95% CI, 1.60 to 2.93; I2=77%), diet (OR, 1.61; 95% CI, 1.10 to 2.36; I2=0%), and urine (OR, 1.49; 95% CI, 1.02 to 2.17; I2=0%) as samples to estimate Se levels, but not in studies on nails (OR, 1.24; 95% CI, 0.52 to 2.98; I2=91%). Because of significant heterogeneity in the studies with blood, we conducted a sensitivity analysis and tested the publication bias. The results were consistent after adjustment based on the sensitivity analysis as well as the trim and fill analysis for publication bias.ConclusionThis meta-analysis demonstrates that high levels of Se are associated with the presence of DM. Further prospective and randomized controlled trials are warranted to elucidate the link better. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2233-6079 2233-6087 |
| Relation: | http://e-dmj.org/upload/pdf/dmj-43-447.pdf; https://doaj.org/toc/2233-6079; https://doaj.org/toc/2233-6087 |
| DOI: | 10.4093/dmj.2018.0123 |
| URL الوصول: | https://doaj.org/article/ba2de8b31f1e448db45af645ef1964e2 |
| رقم الأكسشن: | edsdoj.ba2de8b31f1e448db45af645ef1964e2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22336079 22336087 |
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| DOI: | 10.4093/dmj.2018.0123 |