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FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons

التفاصيل البيبلوغرافية
العنوان: FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons
المؤلفون: Haidun Yan, Juan L Pablo, Chaojian Wang, Geoffrey S Pitt
المصدر: eLife, Vol 3 (2014)
بيانات النشر: eLife Sciences Publications Ltd, 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: resurgent sodium current, cerebellum, spinocerebellar ataxia, cerebellar Purkinje neuron, electrophysiology, Medicine, Science, Biology (General), QH301-705.5
الوصف: Rapid firing of cerebellar Purkinje neurons is facilitated in part by a voltage-gated Na+ (NaV) ‘resurgent’ current, which allows renewed Na+ influx during membrane repolarization. Resurgent current results from unbinding of a blocking particle that competes with normal channel inactivation. The underlying molecular components contributing to resurgent current have not been fully identified. In this study, we show that the NaV channel auxiliary subunit FGF14 ‘b’ isoform, a locus for inherited spinocerebellar ataxias, controls resurgent current and repetitive firing in Purkinje neurons. FGF14 knockdown biased NaV channels towards the inactivated state by decreasing channel availability, diminishing the ‘late’ NaV current, and accelerating channel inactivation rate, thereby reducing resurgent current and repetitive spiking. Critical for these effects was both the alternatively spliced FGF14b N-terminus and direct interaction between FGF14b and the NaV C-terminus. Together, these data suggest that the FGF14b N-terminus is a potent regulator of resurgent NaV current in cerebellar Purkinje neurons.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/04193; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.04193
URL الوصول: https://doaj.org/article/cbaad12c755a48169192b7e5c3aad79a
رقم الأكسشن: edsdoj.baad12c755a48169192b7e5c3aad79a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.04193