دورية أكاديمية
Sustained Response of a Clivus Chordoma to Erlotinib after Imatinib Failure
| العنوان: | Sustained Response of a Clivus Chordoma to Erlotinib after Imatinib Failure |
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| المؤلفون: | Aline Houessinon, Mathieu Boone, Jean-Marc Constans, Patrick Toussaint, Bruno Chauffert |
| المصدر: | Case Reports in Oncology, Vol 8, Iss 1, Pp 25-29 (2015) |
| بيانات النشر: | Karger Publishers, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Imatinib, Chordoma, Erlotinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Chordoma is a rare malignant axial tumour that develops from embryonic remnants of the notochord. Surgery and irradiation are the standard initial treatment. However, local recurrence is frequent and cytotoxic chemotherapy is inefficient. Transient activity of imatinib, a platelet-derived growth factor receptor inhibitor, was described in a phase II study. Activity of epidermal growth factor receptor (EGFR) inhibitors (erlotinib, gefitinib) has also been shown in a few recent case reports. We describe a 68-year-old female in whom clivus chordoma recurred after surgery and radiotherapy. The tumour progressed despite imatinib treatment. A partial and sustained response (28+ months) was obtained using erlotinib, an EGFR inhibitor. Erlotinib should be evaluated in a prospective trial investigating new potential therapies against recurrent chordoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-6575 00037184 |
| Relation: | http://www.karger.com/Article/FullText/371843; https://doaj.org/toc/1662-6575 |
| DOI: | 10.1159/000371843 |
| URL الوصول: | https://doaj.org/article/bb8dc694f294461aa8eff023828f995a |
| رقم الأكسشن: | edsdoj.bb8dc694f294461aa8eff023828f995a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16626575 00037184 |
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| DOI: | 10.1159/000371843 |