دورية أكاديمية
Understanding Aberrant Signaling to Elude Therapy Escape Mechanisms in Myeloproliferative Neoplasms
| العنوان: | Understanding Aberrant Signaling to Elude Therapy Escape Mechanisms in Myeloproliferative Neoplasms |
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| المؤلفون: | Maria Teresa Bochicchio, Valeria Di Battista, Pietro Poggio, Giovanna Carrà, Alessandro Morotti, Mara Brancaccio, Alessandro Lucchesi |
| المصدر: | Cancers, Vol 14, Iss 4, p 972 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | myeloproliferative neoplasms, JAK2, Aurora A, ROCK, drug resistance, cell signaling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Aberrant signaling in myeloproliferative neoplasms may arise from alterations in genes coding for signal transduction proteins or epigenetic regulators. Both mutated and normal cells cooperate, altering fragile balances in bone marrow niches and fueling persistent inflammation through paracrine or systemic signals. Despite the hopes placed in targeted therapies, myeloid proliferative neoplasms remain incurable diseases in patients not eligible for stem cell transplantation. Due to the emergence of drug resistance, patient management is often very difficult in the long term. Unexpected connections among signal transduction pathways highlighted in neoplastic cells suggest new strategies to overcome neoplastic cell adaptation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14040972 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/14/4/972; https://doaj.org/toc/2072-6694 |
| DOI: | 10.3390/cancers14040972 |
| URL الوصول: | https://doaj.org/article/bd703958641b47bc9dea3bc3f024b536 |
| رقم الأكسشن: | edsdoj.bd703958641b47bc9dea3bc3f024b536 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14040972 20726694 |
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| DOI: | 10.3390/cancers14040972 |