دورية أكاديمية
Genomic signatures of local adaptation in recent invasive Aedes aegypti populations in California
| العنوان: | Genomic signatures of local adaptation in recent invasive Aedes aegypti populations in California |
|---|---|
| المؤلفون: | Shaghayegh Soudi, Marc Crepeau, Travis C. Collier, Yoosook Lee, Anthony J. Cornel, Gregory C. Lanzaro |
| المصدر: | BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | Aedes mosquitoes, Genome scan, Landscape genomics, Selection, Adaptive loci, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract Background Rapid adaptation to new environments can facilitate species invasions and range expansions. Understanding the mechanisms of adaptation used by invasive disease vectors in new regions has key implications for mitigating the prevalence and spread of vector-borne disease, although they remain relatively unexplored. Results Here, we integrate whole-genome sequencing data from 96 Aedes aegypti mosquitoes collected from various sites in southern and central California with 25 annual topo-climate variables to investigate genome-wide signals of local adaptation among populations. Patterns of population structure, as inferred using principal components and admixture analysis, were consistent with three genetic clusters. Using various landscape genomics approaches, which all remove the confounding effects of shared ancestry on correlations between genetic and environmental variation, we identified 112 genes showing strong signals of local environmental adaptation associated with one or more topo-climate factors. Some of them have known effects in climate adaptation, such as heat-shock proteins, which shows selective sweep and recent positive selection acting on these genomic regions. Conclusions Our results provide a genome wide perspective on the distribution of adaptive loci and lay the foundation for future work to understand how environmental adaptation in Ae. aegypti impacts the arboviral disease landscape and how such adaptation could help or hinder efforts at population control. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2164 00800104 |
| Relation: | https://doaj.org/toc/1471-2164 |
| DOI: | 10.1186/s12864-023-09402-5 |
| URL الوصول: | https://doaj.org/article/bdeab0080010402c803d58763bd385b5 |
| رقم الأكسشن: | edsdoj.bdeab0080010402c803d58763bd385b5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712164 00800104 |
|---|---|
| DOI: | 10.1186/s12864-023-09402-5 |