دورية أكاديمية
Primary antiphospholipid syndrome evolving into systemic lupus erythematosus: may antinucleosome antibodies be predictive?
| العنوان: | Primary antiphospholipid syndrome evolving into systemic lupus erythematosus: may antinucleosome antibodies be predictive? |
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| المؤلفون: | R.A. Sinico, C. Corace, A. Radice, F. Allegri, V. Fanelli, R.W. Burlingame, F. Pregnolato, L. Andreoli, A. Tinconi, P.L. Meroni |
| المصدر: | Reumatismo, Vol 60, Iss 3, Pp 185-191 (2011) |
| بيانات النشر: | PAGEPress Publications, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Internal medicine |
| مصطلحات موضوعية: | Medicine, Internal medicine, RC31-1245 |
| الوصف: | Objective: It was reported by several groups that patients diagnosed as primary antiphospholipid syndrome (PAPS) had developed a full-blown systemic lupus erythematosus (SLE) even after many years of follow-up. Little is known about clinical and/or serological factors that may help predict such evolution. Antinucleosome antibodies (anti-NCS) were described to appear in early stages of SLE, in particular before anti-dsDNA antibodies. The aim of the study is to evaluate the prevalence of anti-NCS in a large cohort of PAPS patients. Methods: IgG and IgM anti-NCS antibodies were detected using a home made assay with H1-stripped chromatin as antigen. Sera from 106 PAPS patients were tested; 52 of them were also tested during the follow-up, at least 2 years apart form the basal sample. Results: Medium-high titre anti-NCS were found in nearly half of the patients (49/106, 46%), more frequently in those presenting features of “lupus like disease”. Most of patients displayed an unchanged pattern of anti-NCS over time. We describe three cases of PAPS patients that developed SLE after many years of follow-up; high titre and low titre anti-NCS were present in two and one of them respectively several years before evolving into SLE. Conclusions: A significant proportion of PAPS patients displayed medium-high titre anti-NCS, suggesting that the autoimmune response against chromatin may be a relevant event not only in patients with SLE. Further studies are warranted to explore the predictive value of anti-NCS with respect to the evolution from PAPS to SLE. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Italian |
| تدمد: | 0048-7449 2240-2683 |
| Relation: | http://www.reumatismo.org/index.php/reuma/article/view/384; https://doaj.org/toc/0048-7449; https://doaj.org/toc/2240-2683 |
| DOI: | 10.4081/reumatismo.2008.185 |
| URL الوصول: | https://doaj.org/article/cebdee4d23a5463cbffa3dad26137785 |
| رقم الأكسشن: | edsdoj.bdee4d23a5463cbffa3dad26137785 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00487449 22402683 |
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| DOI: | 10.4081/reumatismo.2008.185 |