دورية أكاديمية
Real-world evidence study finds no new-onset diabetes or drug-related hyperglycemia in Pompe disease patients treated with avalglucosidase alfa
| العنوان: | Real-world evidence study finds no new-onset diabetes or drug-related hyperglycemia in Pompe disease patients treated with avalglucosidase alfa |
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| المؤلفون: | Alexandra Dumitriu, Ann Lucas, Raffaella Colzani |
| المصدر: | Molecular Genetics and Metabolism Reports, Vol 38, Iss , Pp 101064- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Avalglucosidase alfa, Pompe disease, Hyperglycemia, Diabetes mellitus, Insulin resistance, Prediabetes, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Avalglucosidase alfa therapy for Pompe disease is diluted in dextrose 5% solution in water (D5W) for infusion, which raises questions about the potential for hyperglycemia or worsening diabetes. Using United States insurance claims data, we assessed the impact of biweekly infusions on hyperglycemia, new-onset diabetes mellitus, insulin resistance, and prediabetes in patients with Pompe disease. After starting avalglucosidase alfa treatment, 1 of 26 patients had one claim for hyperglycemia, which was attributed to acute pancreatitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2214-4269 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S221442692400017X; https://doaj.org/toc/2214-4269 |
| DOI: | 10.1016/j.ymgmr.2024.101064 |
| URL الوصول: | https://doaj.org/article/be3c43f64dfa4bd3ae4ee026ef9e0d7f |
| رقم الأكسشن: | edsdoj.be3c43f64dfa4bd3ae4ee026ef9e0d7f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22144269 |
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| DOI: | 10.1016/j.ymgmr.2024.101064 |