دورية أكاديمية
SSRIs: Applications in inflammatory lung disease and implications for COVID‐19
| العنوان: | SSRIs: Applications in inflammatory lung disease and implications for COVID‐19 |
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| المؤلفون: | Claire Kyung Sun Meikle, Justin Fortune Creeden, Cheryl McCullumsmith, Randall G. Worth |
| المصدر: | Neuropsychopharmacology Reports, Vol 41, Iss 3, Pp 325-335 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | ARDS, COVID‐19, lung inflammation, NF‐κB, selective serotonin reuptake inhibitor, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Abstract Selective serotonin reuptake inhibitors (SSRIs) have anti‐inflammatory properties that may have clinical utility in treating severe pulmonary manifestations of COVID‐19. SSRIs exert anti‐inflammatory effects at three mechanistic levels: (a) inhibition of proinflammatory transcription factor activity, including NF‐κB and STAT3; (b) downregulation of lung tissue damage and proinflammatory cell recruitment via inhibition of cytokines, including IL‐6, IL‐8, TNF‐α, and IL‐1β; and (c) direct suppression inflammatory cells, including T cells, macrophages, and platelets. These pathways are implicated in the pathogenesis of COVID‐19. In this review, we will compare the pathogenesis of lung inflammation in pulmonary diseases including COVID‐19, ARDS, and chronic obstructive pulmonary disease (COPD), describe the anti‐inflammatory properties of SSRIs, and discuss the applications of SSRIS in treating COVID‐19‐associated inflammatory lung disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2574-173X |
| Relation: | https://doaj.org/toc/2574-173X |
| DOI: | 10.1002/npr2.12194 |
| URL الوصول: | https://doaj.org/article/be9e028230e64667b27d1d0f38409936 |
| رقم الأكسشن: | edsdoj.be9e028230e64667b27d1d0f38409936 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2574173X |
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| DOI: | 10.1002/npr2.12194 |