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Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5

التفاصيل البيبلوغرافية
العنوان: Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5
المؤلفون: Prameet Kaur, Vanessa Yuk Man Lam, Anirudh Gautam Mannava, Jahnavi Suresh, Andreas Jenny, Nicholas S. Tolwinski
المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
بيانات النشر: Nature Portfolio, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract The highly conserved Wnt signaling pathway regulates cell proliferation and differentiation in vertebrates and invertebrates. Upon binding of a Wnt ligand to a receptor of the Fz family, Disheveled (Dsh/Dvl) transduces the signal during canonical and non-canonical Wnt signaling. The specific details of how this process occurs have proven difficult to study, especially as Dsh appears to function as a switch between different branches of Wnt signaling. Here we focus on the membrane-proximal events that occur once Dsh is recruited to the membrane. We show that membrane-tethering of the Dsh protein is sufficient to induce canonical Wnt signaling activation even in the absence of the Wnt co-receptor Arrow/LRP5/6. We map the protein domains required for pathway activation in membrane tethered constructs finding that both the DEP and PDZ domains are dispensable for canonical signaling only in membrane-tethered Dsh, but not in untethered/normal Dsh. These data lead to a signal activation model, where Arrow is required to localize Dsh to the membrane during canonical Wnt signaling placing Dsh downstream of Arrow.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-017-04414-0
URL الوصول: https://doaj.org/article/f0b54aded1a04e80b4c93f85536b5bf0
رقم الأكسشن: edsdoj.f0b54aded1a04e80b4c93f85536b5bf0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-017-04414-0