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ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation

التفاصيل البيبلوغرافية
العنوان: ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation
المؤلفون: Jessica Elmore, Chavez Carter, Amie Redko, Nicholas Koylass, Amelia Bennett, Max Mead, Marinel Ocasio-Rivera, Weishan Huang, Ankur Singh, Avery August
المصدر: Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Biology (General), QH301-705.5
الوصف: The kinase Itk is normally required for differentiation of IL-17-producing CD4 T-helper (Th)17 cells however, Elmore, Carter et al. now report that Itk can be bypassed during Th17 differentiation in Saccharopolyspora rectivirgula induced hypersensitivity pneumonitis. This study suggests that some inflammatory signals can override normal T cell activation and differentiation pathways.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2399-3642
Relation: https://doaj.org/toc/2399-3642
DOI: 10.1038/s42003-022-03109-1
URL الوصول: https://doaj.org/article/f149f6e20ad24cd3b72863321fe8bbe9
رقم الأكسشن: edsdoj.f149f6e20ad24cd3b72863321fe8bbe9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23993642
DOI:10.1038/s42003-022-03109-1