دورية أكاديمية
PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions
| العنوان: | PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions |
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| المؤلفون: | Xiaona Huang, Chao Wei, Fenjie Li, Lumeng Jia, Pengguihang Zeng, Jiahe Li, Jin Tan, Tuanfeng Sun, Shaoshuai Jiang, Jia Wang, Xiuxiao Tang, Qingquan Zhao, Bin Liu, Limin Rong, Cheng Li, Junjun Ding |
| المصدر: | Protein & Cell, Vol 10, Iss 10, Pp 709-725 (2019) |
| بيانات النشر: | Oxford University Press, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Cytology LCC:Animal biochemistry |
| مصطلحات موضوعية: | PCGF6, Polycomb group, super-enhancer, 3D chromatin, pluripotency, Cytology, QH573-671, Animal biochemistry, QP501-801 |
| الوصف: | ABSTRACT Polycomb group (PcG) ring finger protein 6 (PCGF6), though known as a member of the transcription-repressing complexes, PcG, also has activation function in regulating pluripotency gene expression. However, the mechanism underlying the activation function of PCGF6 is poorly understood. Here, we found that PCGF6 co-localizes to gene activation regions along with pluripotency factors such as OCT4. In addition, PCGF6 was recruited to a subset of the super-enhancer (SE) regions upstream of cell cycle-associated genes by OCT4, and increased their expression. By combining with promoter capture Hi-C data, we found that PCGF6 activates cell cycle genes by regulating SE-promoter interactions via 3D chromatin. Our findings highlight a novel mechanism of PcG protein in regulating pluripotency, and provide a research basis for the therapeutic application of pluripotent stem cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1674-800X 1674-8018 |
| Relation: | http://link.springer.com/article/10.1007/s13238-019-0629-9; https://doaj.org/toc/1674-800X; https://doaj.org/toc/1674-8018 |
| DOI: | 10.1007/s13238-019-0629-9 |
| URL الوصول: | https://doaj.org/article/f1662bece80242d6a6e8ffd5d9627afa |
| رقم الأكسشن: | edsdoj.f1662bece80242d6a6e8ffd5d9627afa |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1674800X 16748018 |
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| DOI: | 10.1007/s13238-019-0629-9 |