دورية أكاديمية
Pigmented hepatocellular adenoma with β-catenin activation: case report and literature review
| العنوان: | Pigmented hepatocellular adenoma with β-catenin activation: case report and literature review |
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| المؤلفون: | Rosa Coelho, Regina Gonçalves, Fátima Carneiro, Margarida Fernandes, Joanne Lopes, Susana Guimarães, Guilherme Macedo |
| المصدر: | Annals of Hepatology, Vol 15, Iss 4, Pp 598-603 (2016) |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Specialties of internal medicine |
| مصطلحات موضوعية: | Liver cell adenoma, Pigment, Dubin-Johnson pigment, Glutamine synthetase, Liver cell, Specialties of internal medicine, RC581-951 |
| الوصف: | Hepatocellular adenomas (HCAs) are benign liver tumors recently characterized into 4 different types according to genetic, pathological and clinical features. The prognosis is not well established yet and malignant transformation has been recently associated with β-catenin activation. We aimed to describe a case of a pigmented HCA with β-catenin nuclear expression and inflammatory features and to review the cases of pigmented HCAs in the literature. We report a case of a young female patient without contraceptive use, with a liver tumor diagnosis. Liver biopsy revealed diffuse expression of β-catenin and a partial hepatic resection was performed. The histologic analysis revealed a hepatocellular tumor composed of uniform trabeculae of hepatocytes and solid areas, the later with a significant amount of black pigment highlighted by Masson-Fontana stain. Immunohistochemistry showed co-expression of C-reactive protein and serum amyloid A in the tumor. Literature review revealed that pigmented HCAs, previously reported as dark adenomas, are rare tumors. In HCAs, the presence of β-catenin activation should be searched for due to the higher risk of malignant transformation in hepatocarcinoma. We describe a pigmented HCA with β-catenin nuclear expression and inflammatory features being the fifth case reported so far. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1665-2681 16652681 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1665268119311512; https://doaj.org/toc/1665-2681 |
| DOI: | 10.5604/16652681.1203164 |
| URL الوصول: | https://doaj.org/article/f18afb07716e4cc78234cbb3ee8bee8f |
| رقم الأكسشن: | edsdoj.f18afb07716e4cc78234cbb3ee8bee8f |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 16652681 |
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| DOI: | 10.5604/16652681.1203164 |