دورية أكاديمية
Exploiting the Fc base of IgG antibodies to create functional nanoparticle conjugates
| العنوان: | Exploiting the Fc base of IgG antibodies to create functional nanoparticle conjugates |
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| المؤلفون: | Mohammed M. Al Qaraghuli, Karina Kubiak-Ossowska, Valerie A. Ferro, Paul A. Mulheran |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Antibody, Gold nanoparticles, Structural similarity, Antibody function, Molecular dynamics, Medicine, Science |
| الوصف: | Abstract The structures of the Fc base of various IgG antibodies have been examined with a view to understanding how this region can be used to conjugate IgG to nanoparticles. The base structure is found to be largely consistent across a range of species and subtypes, comprising a hydrophobic region surrounded by hydrophilic residues, some of which are charged at physiological conditions. In addition, atomistic Molecular Dynamics simulations were performed to explore how model nanoparticles interact with the base using neutral and negatively charged gold nanoparticles. Both types of nanoparticle interacted readily with the base, leading to an adaptation of the antibody base surface to enhance the interactions. Furthermore, these interactions left the rest of the domain at the base of the Fc region structurally intact. This implies that coupling nanoparticles to the base of an IgG molecule is both feasible and desirable, since it leaves the antibody free to interact with its surroundings so that antigen-binding functionality can be retained. These results will therefore help guide future attempts to develop new nanotechnologies that exploit the unique properties of both antibodies and nanoparticles. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-65822-7 |
| URL الوصول: | https://doaj.org/article/ef239524ae0b4060a8497467731b4148 |
| رقم الأكسشن: | edsdoj.f239524ae0b4060a8497467731b4148 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-65822-7 |