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Association between ABCB1 rs2235048 Polymorphism and THC Pharmacokinetics and Subjective Effects following Smoked Cannabis in Young Adults

التفاصيل البيبلوغرافية
العنوان: Association between ABCB1 rs2235048 Polymorphism and THC Pharmacokinetics and Subjective Effects following Smoked Cannabis in Young Adults
المؤلفون: Justin Matheson, Yollanda J. Zhang, Bruna Brands, Christine M. Wickens, Arun K. Tiwari, Clement C. Zai, James L. Kennedy, Bernard Le Foll
المصدر: Brain Sciences, Vol 12, Iss 9, p 1189 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
مصطلحات موضوعية: cannabis, THC, ABCB1, P-glycoprotein, pharmacogenetics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Genetic influences on acute responses to psychoactive drugs may contribute to individual variability in addiction risk. ABCB1 is a human gene that encodes P-glycoprotein, an ATP-dependent efflux pump that may influence the pharmacokinetics of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Using data from 48 young adults (aged 19–25 years) reporting 1–4 days of cannabis use per week who completed a placebo-controlled human laboratory experiment, we tested the hypothesis that the rs2235048 polymorphism of ABCB1 would influence acute responses to smoked cannabis. C-allele carriers reported on average greater frequency of weekly cannabis use compared to the TT genotype carriers (TC/CC mean ± SEM = 2.74 ± 0.14, TT = 1.85 ± 0.24, p = 0.004). After smoking a single cannabis cigarette to their desired high, C-allele carriers had higher area-under-the-curve (AUC) of both THC metabolites (11-OH-THC TC/CC = 7.18 ± 9.64, TT = 3.28 ± 3.40, p = 0.05; THC-COOH TC/CC = 95.21 ± 116.12, TT = 45.92 ± 42.38, p = 0.043), and these results were impact by self-reported ethnicity. There were no significant differences in self-reported subjective drug effects except for a greater AUC of visual analogue scale rating of drug liking (TC/CC = 35,398.33 ± 37,233.72, TT = 15,895.56 ± 13,200.68, p = 0.017). Our preliminary findings suggest that further work in a larger sample should investigate whether human ABCB1 influences cannabis-related phenotypes and plays a role in the risk of developing a cannabis use disorder.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 12091189
2076-3425
Relation: https://www.mdpi.com/2076-3425/12/9/1189; https://doaj.org/toc/2076-3425
DOI: 10.3390/brainsci12091189
URL الوصول: https://doaj.org/article/f5239537f25a41f5b7e9bd6392a6d22e
رقم الأكسشن: edsdoj.f5239537f25a41f5b7e9bd6392a6d22e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:12091189
20763425
DOI:10.3390/brainsci12091189